A0A977K920 · A0A977K920_9CREN

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site73Nucleophile
Active site174
Active site176

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhydrolase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisH
  • EC number
  • Alternative names
    • IGP synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • IGP synthase subunit HisH
    • ImGP synthase subunit HisH
      (IGPS subunit HisH
      )

Gene names

    • Name
      hisH
    • ORF names
      IPA_01575

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 13166
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Desulfurococcales > Desulfurococcaceae > Ignicoccus

Accessions

  • Primary accession
    A0A977K920

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-188Glutamine amidotransferase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    195
  • Mass (Da)
    22,051
  • Last updated
    2023-02-22 v1
  • Checksum
    179E30A572EDD75B
MVDYGIGNTFSIRNGLQRVGFRAVLTKDLETLRRADLVVLPGVGSHQAAMSNIERYKLIDYLKDPDGWVLGICLGMQLLYERSEEGGLKGLGLLKGEVIRFRGVRKVPHMGWNEVNASKETPLLEGIEGRNFYFAHSFYKPFEGREEELGITEYEGVKFTSLVQKGKIIGTQFHPEKSSSAGRKFLENLAREIRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006868
EMBL· GenBank· DDBJ
UXD21232.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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