A0A975INS6 · A0A975INS6_LOWBP

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

129520406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site73Zn2+ 1 (UniProtKB | ChEBI)
Binding site113Zn2+ 1 (UniProtKB | ChEBI)
Binding site150Zn2+ 1 (UniProtKB | ChEBI)
Binding site150Zn2+ 2 (UniProtKB | ChEBI)
Binding site184Zn2+ 2 (UniProtKB | ChEBI)
Binding site187Zn2+ 3 (UniProtKB | ChEBI)
Binding site219Zn2+ 2 (UniProtKB | ChEBI)
Binding site232Zn2+ 3 (UniProtKB | ChEBI)
Binding site234Zn2+ 3 (UniProtKB | ChEBI)
Binding site264Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      LFWB_6550

Organism names

  • Taxonomic identifier
  • Strain
    • NCHU2019
  • Taxonomic lineage
    Bacteria > Mycoplasmatota > Mollicutes > Acholeplasmatales > Acholeplasmataceae > Candidatus Phytoplasma > 16SrVIII (Loofah witches'-broom group)

Accessions

  • Primary accession
    A0A975INS6

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-283Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    295
  • Mass (Da)
    34,105
  • Last updated
    2023-02-22 v1
  • Checksum
    C59D702AC6053CCF
MNKLIIGSHISFKQPFFYLNTLQQALSFGANTFMIYTGAPQNTKRPDFNKIYLSETLIEMKKNSFQFNNLVGHAPYIINLANLSIEKRNFAISFLTEELKKFEILKIPQMVLHPGNSLQQERKEAIKMIAQGINQIFKNTSDLKIKIALETMSGKGTEIGYKFQELKNIIDLIEDKTRISVCFDTCHVFDAGYDIKNNFNLVMEEFNNIIGYKYLSVVHINDSKNILGSKKDRHENIGYGKIGFDSLMKIIYSPFFKSLPKILETPFINDQPPYEAEIKMIKEKKFNPYLKKIIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP054393
EMBL· GenBank· DDBJ
QTX03216.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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