A0A974HC40 · A0A974HC40_XENLA

Function

Catalytic activity

  • Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
    EC:3.4.23.46 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

150350100150200250300350400450500
TypeIDPosition(s)Description
Active site95
Active site291

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcell surface
Cellular Componentdendrite
Cellular Componentearly endosome
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentlate endosome
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentrecycling endosome
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-secretase 1
  • EC number
  • Alternative names
    • Beta-site amyloid precursor protein cleaving enzyme 1
    • Memapsin-2
    • Membrane-associated aspartic protease 2

Gene names

    • Name
      bace1.L
    • ORF names
      XELAEV_18035449mg

Organism names

  • Taxonomic identifier
  • Strain
    • J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A0A974HC40

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Cell projection, axon
Cell projection, dendrite
Cell surface
Early endosome
Endosome
Late endosome
Membrane raft
Membrane
; Single-pass type I membrane protein
Recycling endosome

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane461-480Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_503793007827-503Beta-secretase 1

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain77-418Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    56,149
  • Last updated
    2023-02-22 v1
  • Checksum
    04C8E12D3EFD755B
MELVLYAHGGSILLLVLLPCFLPAAGQVAIKLPLKNCPGTCSPPGYRAKRSVEKGTEQDTNFLDMIDNLRGKSGQGYYVEMRVGTPPQTLNILVDTGSSNFAVGAAPHPFLKRYYHRQRSRTYRDVRRGVYVPYTQGKWEGELGTDLVTIPHGPNVTVTANIAAITDSDKFFINGSNWEGILGLAYAEIARPDDTLEPFFDSLVKQTRVPNIFSLQLCGTGFHINESDTIASVGGSMVIGGIDHSLYIGSIWYTPIRKEWYYEVIIVKIEINGQDLHMDCKEYNYDKSIVDSGTTNLRLPKRVFDAAVKSIKAASATEKFPDGFWMGEQLVCWQEGTTPWHIFPVISLYLMGEVANQSFKITILPQQYLRPVEDIATAQEDCYKFAVSQSTTGTVMGAVIMEGFYVVFDRADKRIGFAVSACHVHDYFRMASVEGPFFASDLEDCGYNTPQLDESALMTTAYVMAGVCALFMLPLCLMLFQWRCFRCLKRARDDLADDISLLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM004478
EMBL· GenBank· DDBJ
OCT72470.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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