A0A974HAG9 · A0A974HAG9_XENLA

Function

function

GTPase-activating protein for the ADP ribosylation factor family.

Activity regulation

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome membrane
Molecular FunctionGTPase activator activity
Molecular Functionmetal ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
  • Short names
    Cnt-b
  • Alternative names
    • Centaurin-beta

Gene names

    • ORF names
      XELAEV_18037504mg

Organism names

  • Taxonomic identifier
  • Strain
    • J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A0A974HAG9

Proteomes

Subcellular Location

Endosome membrane
; Peripheral membrane protein

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

TypeIDPosition(s)Description
Domain264-359PH
Domain399-521Arf-GAP
Region537-564Disordered
Region616-646Disordered
Compositional bias664-684Acidic residues
Region664-690Disordered
Repeat727-759ANK
Repeat760-792ANK

Domain

PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    867
  • Mass (Da)
    97,823
  • Last updated
    2023-02-22 v1
  • Checksum
    ECF4A6537B9A7D7B
MTVDFEECIKDSPRFRASIDEVETDVVEIEAKLDKLVKLCSSMLEAGKTYLTTNKHFVSGIRDLSQQCKKDEMISECLDKFGDSLKEMVNYHMILFDQAQRSVRQQLHIFVKDDVRKFKESKKQFDKVREDLDIALVKNAQAPRHKLHEVEEASSTLTITRKCFRHLALDYVLQINVLQAKKKFEILDAMLSFMHAQYTFFQQGYSLLNELNPYMKQLASELDQLVIDSAVEKREMEHKHATIQQRDFSYDDSKADFNVDAPNGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDVLTVVVEDLRLCTVKPCEDIERRFCFEVVSPSKSCMLQADSEKLRQSWIQAVQASIASAYRETPDNYYIERLDRTASPSTSSIDSASDSRERSVKGESILQRVQSIAGNDQCCDCGQTDPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDSWEPELLKLMCELGNSTINQIYEAKCEHLGLKKPTSGCSRQNKEIWIKAKYVEKKFLKRLGTVEVENDRKPQRWSMKKCHRNNSTTKVPSTRRKFRHEMGSASPAMLSSAAKMERKFRRDSLFCPDELDSLFSYFDTGSGPRSVNLLPAQHPLPAVPWTGSGAEPGGSAMPFLRDGGLSSDSGLGGSTDGSSDILVFGAVVDSVTEEECEVSEDSSGEAETEQEPSDPEDLRELHPGLLMYRASRARNLPFMAEALANGANVNWVNDEDESKTPLIQAVLGGSLIACEFLLQNGADVNQTDMRGRAPIHHATYLGHTGQVCLFLKRGANQHAVDEDGQDPLSIAVQAANADIVTLLRLARMNEEMREAEGPFGQPGDTTYLDIFREFSHMASNNPEKLSRRSVHFSNSCR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias664-684Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM004479
EMBL· GenBank· DDBJ
OCT70580.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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