A0A974H061 · A0A974H061_XENLA

Function

function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.

Catalytic activity

Features

Showing features for binding site.

124120406080100120140160180200220240
TypeIDPosition(s)Description
Binding site27-32ATP (UniProtKB | ChEBI)
Binding site48AMP (UniProtKB | ChEBI)
Binding site53AMP (UniProtKB | ChEBI)
Binding site74-76AMP (UniProtKB | ChEBI)
Binding site102-105AMP (UniProtKB | ChEBI)
Binding site109AMP (UniProtKB | ChEBI)
Binding site144ATP (UniProtKB | ChEBI)
Binding site153-154ATP (UniProtKB | ChEBI)
Binding site177AMP (UniProtKB | ChEBI)
Binding site188AMP (UniProtKB | ChEBI)
Binding site216ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial intermembrane space
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Biological ProcessADP biosynthetic process
Biological ProcessAMP metabolic process
Biological ProcessATP metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase 2, mitochondrial
  • EC number
  • Short names
    AK 2
  • Alternative names
    • ATP-AMP transphosphorylase 2
    • ATP:AMP phosphotransferase
    • Adenylate monophosphate kinase

Gene names

    • Name
      AK2
    • ORF names
      XELAEV_18004050mg

Organism names

  • Taxonomic identifier
  • Strain
    • J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A0A974H061

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond44↔94

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region47-76NMPbind
Region143-180LID
Domain144-179Adenylate kinase active site lid

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. AK2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    26,495
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    E6B794121442F7F08731B9A272A7124F
MAPREAAPAERGSVMEGIRAILLGPPGAGKGTQAPKLAEKYCVCHLATGDMLRAMVASGSELGKRLKATMDAGKLVSDEMVVELIEKNLDTPPCKKGFLLDGFPRTVKQAEMLDELLEKRQEKLDSVIEFKVDDSLLVRRICGRLIHASSGRSYHEEFNPPKEPMKDDVTGEALIRRSDDNESTLKSRLEAYHTMTSPLVDYYQRHGIHTAVDAAQSPDVVFASILAAFSKAHCKDLVLFV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV467236
EMBL· GenBank· DDBJ
OCT57047.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help