A0A974GZ82 · A0A974GZ82_XENLA
- Proteinreceptor protein-tyrosine kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids718 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 339 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 367-374 | ATP (UniProtKB | ChEBI) | |||
Binding site | 394 | ATP (UniProtKB | ChEBI) | |||
Binding site | 442-448 | ATP (UniProtKB | ChEBI) | |||
Active site | 550 | Proton acceptor | |||
Binding site | 554 | ATP (UniProtKB | ChEBI) | |||
Binding site | 555 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 568 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | growth factor binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | B cell differentiation | |
Biological Process | hematopoietic progenitor cell differentiation | |
Biological Process | Kit signaling pathway | |
Biological Process | positive regulation of cell migration | |
Biological Process | positive regulation of MAP kinase activity | |
Biological Process | positive regulation of receptor signaling pathway via JAK-STAT | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionA0A974GZ82
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 298-319 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-82 | Ig-like | |||
Domain | 189-278 | Ig-like | |||
Domain | 360-687 | Protein kinase | |||
Region | 494-516 | Disordered | |||
Compositional bias | 498-513 | Polar residues | |||
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length718
- Mass (Da)80,021
- Last updated2023-02-22 v1
- MD5 Checksum8E33596C30561A9FD05CD2BFEC0F35E3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 498-513 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV467312 EMBL· GenBank· DDBJ | OCT56285.1 EMBL· GenBank· DDBJ | Genomic DNA |