A0A974CQF9 · A0A974CQF9_XENLA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1213 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 332 | ||||
Binding site | 333 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 362 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 364 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 379 | ||||
Binding site | 413 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Molecular Function | calcium ion binding | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | memory | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionA0A974CQF9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 470-540 | Disordered | |||
Compositional bias | 484-501 | Polar residues | |||
Compositional bias | 508-524 | Acidic residues | |||
Domain | 543-659 | PI-PLC Y-box | |||
Domain | 659-789 | C2 | |||
Region | 841-891 | Disordered | |||
Compositional bias | 867-890 | Polar residues | |||
Region | 973-994 | Disordered | |||
Region | 1060-1089 | Disordered | |||
Region | 1161-1213 | Disordered | |||
Compositional bias | 1170-1192 | Polar residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,213
- Mass (Da)138,172
- Last updated2023-02-22 v1
- Checksum02A7D7C7D3D79C5C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 484-501 | Polar residues | |||
Compositional bias | 508-524 | Acidic residues | |||
Compositional bias | 867-890 | Polar residues | |||
Compositional bias | 1170-1192 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM004475 EMBL· GenBank· DDBJ | OCT77725.1 EMBL· GenBank· DDBJ | Genomic DNA |