A0A974BW21 · A0A974BW21_XENLA

Function

function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.

Catalytic activity

Features

Showing features for active site.

110911002003004005006007008009001,000
TypeIDPosition(s)Description
Active site750Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionATP citrate synthase activity
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process
Biological Processcitrate metabolic process
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-citrate synthase
  • EC number
  • Alternative names
    • ATP-citrate (pro-S-)-lyase
    • Citrate cleavage enzyme

Gene names

    • Name
      acly.L
    • ORF names
      XELAEV_18043093mg

Organism names

  • Taxonomic identifier
  • Strain
    • J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A0A974BW21

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias441-461Polar residues
Region441-472Disordered
Domain482-591CoA-binding

Sequence similarities

In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,091
  • Mass (Da)
    119,860
  • Last updated
    2023-02-22 v1
  • Checksum
    AC1C3045510437E6
MSAKAISEQTGKEFLYKFICTSAAVQNRFKYAHVTYDTDWDRLTQEHPWLLTEPLVVKPDQLIKRRGKLGLVGVNLNLEQVKSWLKARLGHETTIAKAKGILKNFLIEPFVPHKQEEEYYVCIYAAREGDYVLFHHEGGVDVGDVDSKAQKLLVGVGERLTEQQVKSQLLIHVAQDKKEVLSSFITGLFNLYEDLYFTYLEINPLVVTQNGVYVLDMAAKIDATADYICKAKWGDVEFPPPFGREAYPEEAYIADLDAKSGASLKLTILNPRGRIWTMVAGGGASVVYSDTICDLGGVDELANYGEYSGAPSEQQTYDYAKTILSLMTREKHSDGKILIIGGSIANFTNVAATFKGIVRAIKDSQGPLKEHEVMIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSSSTPAPSRTASFSESRTEDITPAKKSKPAIPNAKATTLFTRHTKSIVWGMQTRAVQGMLDFDYICSRSEPSVAALVYPFTGDHKQKFYWGHKEILIPVFKNMADAMKKHPEVDVLINFASLRSAYDSTIETMNFPQIRAIAIIAEGIPEALTRKLIKMADEKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVFEGVAIGGDRYPASTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQAMKEAGVFVPRSFDELGDVIQSVYEDLVAKGEIVPAEEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITDVFKEDLGIGGVLGLLWFQRRMPKYASHFIEMCLMVTADHGPAVSGAHNSIVCARAGKDLISSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGLIPMDFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVKQNFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDLLRTCGTFTREEADEYVEIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMTM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias441-461Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM004482
EMBL· GenBank· DDBJ
OCT62009.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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