A0A972JTY6 · A0A972JTY6_9CHLR
- ProteinNADH-quinone oxidoreductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids912 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | molybdopterin cofactor binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | quinone binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Chloroflexota
Accessions
- Primary accessionA0A972JTY6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-103 | 2Fe-2S ferredoxin-type | |||
Domain | 103-142 | 4Fe-4S His(Cys)3-ligated-type | |||
Domain | 242-298 | 4Fe-4S Mo/W bis-MGD-type | |||
Sequence similarities
Belongs to the complex I 75 kDa subunit family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length912
- Mass (Da)99,575
- Last updated2023-02-22 v1
- Checksum4CA4E37D600184CF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WYDX01000012 EMBL· GenBank· DDBJ | NOK83589.1 EMBL· GenBank· DDBJ | Genomic DNA |