A0A962UD65 · A0A962UD65_9GAMM

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • Name
      folC
    • ORF names
      KDJ24_20290

Organism names

Accessions

  • Primary accession
    A0A962UD65

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-187Mur ligase central
Domain287-359Mur ligase C-terminal

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    365
  • Mass (Da)
    38,945
  • Last updated
    2023-02-22 v1
  • Checksum
    A4A2E861FA77EC52
MRFTSLPAWLDWQAGLSPKAIDLGLDRVAEVWARLGAPSLDAAVITIAGTNGKGSSVAFAEAILTAAGYRCGCYTSPHLLHYNERIRIDGRCAADEAISAAFARIDDARRDITLTYFEFGTLAALLLFADAGLDAVILEVGLGGRLDAVNLIDADVGVITGIALDHQDWLGEDREAIGYEKAGIMRRGRPVVFSGREMPDSVRAHARSIGALLQVAGEDFQIERHAGQWDLLHAARVRRALPLPGLRGAVQIENAAGVLVALDCLAGRLPIDQAAVRQGLLNARVAGRFEVRPGQPTWVLDVAHNPQAAQTLAANLGDLFVSGQTVAVCGMLADKDAAAVAATLAARFDRWYLVDLSDDLRGLRA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue365

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGRHA010000479
EMBL· GenBank· DDBJ
MCB1792660.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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