A0A962C4V5 · A0A962C4V5_9GAMM

  • Protein
    Dihydrofolate synthase/folylpolyglutamate synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      KDI69_07845

Organism names

Accessions

  • Primary accession
    A0A962C4V5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain128-252Mur ligase C-terminal

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    265
  • Mass (Da)
    28,051
  • Last updated
    2023-02-22 v1
  • Checksum
    EAFB5BEB0E1980C4
PTTIALDHVEQLGPDREAIAREKAGIFRVGRPAVISEFDPPDTLLREVERIGAVPVRAGKHYRFEAASPAWVWSDESEAIELPVPGLEAPAQMANAAAAIAALRALVPALPIPNEAMARGLSDVRLAGRMQRIAGPVEIVLDVAHNPQAAQQLALWLQQHRARGATLAVFAGLADKDVANEVAALMGRIDIWHLAGLSGQGARGQTVESLWAKIGSLLSRSLVIRHVDVATALAEARRSAQAGDRIVVFGSFHTVGEALAALDAG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGRJW010000348
EMBL· GenBank· DDBJ
MCB1568705.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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