A0A960AI80 · A0A960AI80_9ACTN
- ProteinK(+)-insensitive pyrophosphate-energized proton pump
- GenehppA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids782 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Catalytic activity
- diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate
Cofactor
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 502 | Determinant of potassium independence | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameK(+)-insensitive pyrophosphate-energized proton pump
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota
Accessions
- Primary accessionA0A960AI80
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-39 | Helical | ||||
Sequence: TVIVVALIALLALVVAGLLV | ||||||
Transmembrane | 71-89 | Helical | ||||
Sequence: FRTLSIFAVIVFFVLFLLP | ||||||
Transmembrane | 101-124 | Helical | ||||
Sequence: IFFLVGAVFSAVTGYVGMWLAVRA | ||||||
Transmembrane | 145-171 | Helical | ||||
Sequence: IAFRTGGVAGMFTVGLGLLGAAIVVLV | ||||||
Transmembrane | 183-201 | Helical | ||||
Sequence: FGFGAALLAMFMRVGGGIF | ||||||
Transmembrane | 249-267 | Helical | ||||
Sequence: FESYAVTLVAALILGQAAL | ||||||
Transmembrane | 273-293 | Helical | ||||
Sequence: VIPLVIPAIGVLTAMIGIFAV | ||||||
Transmembrane | 305-329 | Helical | ||||
Sequence: AINRGFFISAIISAVLVTIAAFIWL | ||||||
Transmembrane | 360-382 | Helical | ||||
Sequence: FLVIAAVLIGIILAAAIQQLTGY | ||||||
Transmembrane | 394-412 | Helical | ||||
Sequence: VARTSLTGPATVILSGISL | ||||||
Transmembrane | 418-436 | Helical | ||||
Sequence: VYSALLIGAAVYGAFLLGA | ||||||
Transmembrane | 443-463 | Helical | ||||
Sequence: LFAVALAGTGLLTTVGVIVAM | ||||||
Transmembrane | 562-592 | Helical | ||||
Sequence: LVGLLIGASVVFLFSGLAINAVTRAAGAIIF | ||||||
Transmembrane | 632-648 | Helical | ||||
Sequence: GLLAILTPIAVGFGLGI | ||||||
Transmembrane | 720-739 | Helical | ||||
Sequence: LIKVMNLVSLLIAPAVVSMF | ||||||
Transmembrane | 745-764 | Helical | ||||
Sequence: LRWAIALGALAIVVGAVVIT |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length782
- Mass (Da)80,000
- Last updated2023-02-22 v1
- ChecksumE99C2E9B9EB432EA