A0A951P7M4 · A0A951P7M4_9CYAN
- ProteinNucleoside diphosphate kinase
- Genendk
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids149 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
(Microbial infection) Catalyzes the phosphorylation of dZDP to dZTP, when the bacterium is infected by a phage that produces the substrate for the synthesis of dZTP (2- amino-2'-deoxyadenosine 5'-triphosphate), which is then used by the phage as a DNA polymerase substrate.
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- ATP + dZDP = ADP + dZTP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 57 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 85 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 91 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 102 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 112 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 115 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDK ; NDP kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Oculatellales > Oculatellaceae > Pegethrix
Accessions
- Primary accessionA0A951P7M4
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-138 | Nucleoside diphosphate kinase-like | ||||
Sequence: MERTFIAIKPDGVQRQIIGEIIRRFESKGFTLVGLKIMQVSRELAEQHYAVHKERPFFPGLVNFIISAPLVAMVWEGEGVIASARKLIGATNPLTAEPGTIRGDFGVSVGRNLIHGSDAPETAAEEIKLWFKDEELVS |
Sequence similarities
Belongs to the NDK family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length149
- Mass (Da)16,618
- Last updated2023-02-22 v1
- Checksum07D626830EC2FEF8