A0A950I3I4 · A0A950I3I4_9BURK

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site122(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site126-128(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site229Plays an important role in substrate specificity
Binding site245(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine biosynthetic process from serine
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      JO224_11595

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CP_BE_RX_R2_4
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Roseateles

Accessions

  • Primary accession
    A0A950I3I4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue230N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-385Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    416
  • Mass (Da)
    45,134
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    B7EA5E4CD05EA1F3F853F5543B855790
MFDRNTSTIAQVDAEVWAAIQAENRRQEDHIELIASENYCSPAVMQAQGSQLTNKYAEGYPGKRYYGGCENVDVVEQLAIDRLKQLYGANFANVQPNSGSQANQGVFFALLQPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVISYGLDAQEDIDYEAMERLAREKKPKLIIAGASAFSLRIDFERFGRIAKEIGAYFMVDMAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIILSNDEAIAKKINSAIFPGIQGGPLMHVIAGKAVAFKEALTPEFKAYQQQVVANAKVLADTLIERGLRIVSGRTESHVMLVDLRPKGLTGKQAEAILGAAHMTCNKNGIPNDPQKPMVTSGIRLGTPALTTRGFKEEQVRAVAHLIADVLDSPHDEANLATVRAKVAALTRDFPVYR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFAMW010000060
EMBL· GenBank· DDBJ
MBV8605321.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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