A0A949UK97 · A0A949UK97_9GAMM

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

115320406080100120140
TypeIDPosition(s)Description
Active site115
Active site133

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      KUG83_10885

Organism names

Accessions

  • Primary accession
    A0A949UK97

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane59-79Helical
Transmembrane88-105Helical
Transmembrane125-148Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    16,896
  • Last updated
    2023-02-22 v1
  • Checksum
    E03A7EEC5DA54E30
MLHWLWLTLLVIVLDQVTKQIASAMLALYQPIMVMPLFNFTLAHNYGAAFSFLSDAGGWQRYALAAVALITSIGITIWLKRLPKDDPWMAASLSLILGGAIGNLYDRVVLGYVVDFLDVYWGASHFPAFNIADSAISIGAAMMVIDLIRNPHK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHRVS010000427
EMBL· GenBank· DDBJ
MBV1873041.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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