A0A941T3U6 · A0A941T3U6_UNCPS

Function

function

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentouter membrane-bounded periplasmic space
Molecular Functionpeptide binding
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Molecular Functionunfolded protein binding
Biological ProcessGram-negative-bacterium-type cell outer membrane assembly
Biological Processprotein folding
Biological Processprotein stabilization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Chaperone SurA
  • Alternative names
    • Peptidyl-prolyl cis-trans isomerase SurA
      (PPIase SurA
      ) (EC:5.2.1.8
      ) . EC:5.2.1.8 (UniProtKB | ENZYME | Rhea)
    • Rotamase SurA

Gene names

    • Name
      surA
    • ORF names
      JSR42_00225

Organism names

Accessions

  • Primary accession
    A0A941T3U6

Proteomes

Subcellular Location

Periplasm
Note: Is capable of associating with the outer membrane.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_503820185223-438Chaperone SurA

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain179-280PpiC
Domain292-390PpiC

Domain

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    438
  • Mass (Da)
    48,702
  • Last updated
    2023-02-22 v1
  • Checksum
    84EE195805FB1730
MNRLFSRSCAALAIGFSCAMLAMPLAAAPRAVDVDRIAAVVNNEVITQQELRVRVDQATRQLKRQNVDLPPADVLERQVLERLILERAQLQLARDTSLRVDDATLERAIARIAENNKIGIDQLRATLEKDGVSWNQFRDQIRTEILLTRLREREVDSKVVVTDAEVDNFLASNPDAFSNQEYLLSHILIGAPERPTPEQIERLRARAESAMSRLRAGEDFARVAAAMSDAPDGINGGSLGWRRLDRVPALFAEVARNLKPGEVSEPMRSAAGIHIVKLMDRRGGEGAAALTLEQTHARHILIKTSEVLSDAEAESRLRGLRERIVNGADFGELAKASSADLTAAKGGDLGWVNPGDTVPEFERAMNALKPGEVSQPVRSPFGWHLIQVLGRRVQDVTDERKRGLARAALRERKAEQAYEDWLRQLRDSTYVDNRLGRE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFEFC010000002
EMBL· GenBank· DDBJ
MBS0509596.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp