A0A941PRA4 · A0A941PRA4_UNCPS

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site119Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site120Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site156substrate
Binding site182substrate
Site192-193Cleavage; by autolysis
Active site193Nucleophile
Binding site193substrate
Binding site280substrate
Binding site404substrate
Binding site409substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process

Keywords

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      JSS18_10135

Organism names

Accessions

  • Primary accession
    A0A941PRA4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50381833191-192Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5038183318193-409Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    42,552
  • Last updated
    2023-02-22 v1
  • Checksum
    51C97F860DD90D65
MPVNLTATDPAQLLPVAGVRLGVTQAGVRKAGRDDLTVLLLDEGASVGGVFTQNRFCAAPVQVCREHLTGGAPIRAIVVNTGNANAGTGEDGLQRARATCAALAGLLHIEPRQVLPLSTGVIMEPLPVERIEAGLPAAIAAAGADQWGRAASAIMTTDTVPKAFSTKLRIGGAEVSVTGISKGAGMIRPNMATMLGFVATDACIAPALLTPLARELAEGSFNRVTVDGDTSTNDSFLLIATQRAGHAPITSLASAEGQALKAALLDVARRLAQAIVRDGEGATKFITVRVEGGRDTAECRQVAYAIAHSPLVKTAFFASDPNLGRILAAVGYAGILDLDQTRIDLHLDDVHVATGGGRHPAYREEDGQRVMKQAEITVRVGLGRGAASDTVWTCDLSHDYVSINADYRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFEDZ010000254
EMBL· GenBank· DDBJ
MBS0402824.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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