A0A941PM80 · A0A941PM80_UNCPS

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site139Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site140Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site174substrate
Binding site200substrate
Site210-211Cleavage; by autolysis
Active site211Nucleophile
Binding site211substrate
Binding site298substrate
Binding site421substrate
Binding site426substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process

Keywords

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      JSS00_07580

Organism names

Accessions

  • Primary accession
    A0A941PM80

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50381934191-210Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5038193418211-426Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    426
  • Mass (Da)
    43,834
  • Last updated
    2023-02-22 v1
  • Checksum
    E9376834F846DFF7
MDGDNNQCGSIAVSGPAARVSPLAPKRFPDLPAIAGVEAGIGRAGLYKHERPDLLLMRFAAGARAAGVFTTNAVGSAPTDWCKQALSAGRGSVRGILVNAGCANSFTGPAGDAACKRALEAAAAQIGVGGAREMLAASTGVIGVVLDADKIEGALAGIELGPVRWPEAASAIMTTDTFAKGAGATCEIDGVKVSLAGIAKGSGMIAPNMATMLAFVFTDAALSTPVLKSLLRAETEASFNSITVDGDRSTNDCVLLFATGQAKIPPIADAKDARLDSFRAALGQVLRDLAIQIVRDGEGATKLVAVNVDGAASDASAKAIARTICESPLVKTAIAGGDANWGRIVMAIGRADQPIRREMISVRFGDLFAARDGMIATEYDEGAMSAYMKRDELEISVTVGGGSGRARMYTCDLTKRYVEINGDYRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFEDV010000316
EMBL· GenBank· DDBJ
MBS0385195.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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