A0A941NUU0 · A0A941NUU0_UNCPS
- Protein3-oxoacyl-[acyl-carrier-protein] synthase 2
- GenefabF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids416 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
Catalytic activity
- (9Z)-hexadecenoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxo-(11Z)-octadecenoyl-[ACP] + holo-[ACP] + CO2
- a fatty acyl-[ACP] + malonyl-[ACP] + H+ = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 168 | For beta-ketoacyl synthase activity | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-oxoacyl-[acyl-carrier-protein] synthase 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota
Accessions
- Primary accessionA0A941NUU0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 137-157 | Helical | ||||
Sequence: FFIPGAIINMSAGYFSIMYGY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-415 | Ketosynthase family 3 (KS3) | ||||
Sequence: QRRVVVTGLGVISPVGNDVETSWRNILAGKSGIRLIDTFDVTNFSAKIGGLVRDFDPQLYGISPKEARKMDFFVQYGIAAAVQAVNDAGLKPHPENASRIGVSIGSGIGGLGFIEKNHDEFRDSGPRRISPFFIPGAIINMSAGYFSIMYGYKGPNLAFATACTTGAHSIGMAARCIAYGDADIMVAGGAEKASTPLGLGGFAASRALSTRNEAPEQASRPWDVQRDGFVLGDGASVLVLEEYENAKKRGAKIYAEIIGFGMSASAYHITSYSEGGIGEAAAMIAALNDAKLSPEAVDYVNAHGTSTPVGDVGECLAIKAALGAHAKKIAVSSTKSMTGHLLGAAGAIESMFSVLALRDQIAPPTINLEQTSEDCDLDFVPNVAREMKMDVCISNSFGFGGTNAALVFKR |
Sequence similarities
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)43,603
- Last updated2023-02-22 v1
- ChecksumE992EB4FFA207653