A0A940DLX2 · A0A940DLX2_9BACT
- ProteinErythronate-4-phosphate dehydrogenase
- GenepdxB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids345 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
Catalytic activity
- 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH + H+
Pathway
Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 45 | substrate | |||
Binding site | 66 | substrate | |||
Binding site | 147 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 205 | ||||
Binding site | 227 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 232 | ||||
Active site | 249 | Proton donor | |||
Binding site | 252 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 253 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4-phosphoerythronate dehydrogenase activity | |
Molecular Function | NAD binding | |
Biological Process | pyridoxine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameErythronate-4-phosphate dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Bacteroidia > Bacteroidales > Candidatus Cryptobacteroides
Accessions
- Primary accessionA0A940DLX2
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 19-114 | D-isomer specific 2-hydroxyacid dehydrogenase catalytic | |||
Domain | 115-251 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding | |||
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length345
- Mass (Da)38,227
- Last updated2023-02-22 v1
- MD5 Checksum11F2A4059534D4BD76F07EE588E68E72
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JADIMJ010000036 EMBL· GenBank· DDBJ | MBO8453522.1 EMBL· GenBank· DDBJ | Genomic DNA |