A0A940DLL6 · A0A940DLL6_9BACT

Function

function

Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site49L-glutamine (UniProtKB | ChEBI)
Binding site225L-glutamine (UniProtKB | ChEBI)
Binding site227L-glutamine (UniProtKB | ChEBI)
Active site253Nucleophile
Binding site254L-glutamine (UniProtKB | ChEBI)
Binding site257L-glutamine (UniProtKB | ChEBI)
Binding site295L-glutamine (UniProtKB | ChEBI)
Binding site297L-glutamine (UniProtKB | ChEBI)
Binding site298L-glutamine (UniProtKB | ChEBI)
Active site337
Active site339

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessL-arginine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase small chain
  • EC number
  • Alternative names
    • Carbamoyl phosphate synthetase glutamine chain

Gene names

    • Name
      carA
    • ORF names
      IAC07_00105

Organism names

Accessions

  • Primary accession
    A0A940DLL6

Proteomes

Interaction

Subunit

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-179CPSase
Domain5-144Carbamoyl-phosphate synthase small subunit N-terminal

Sequence similarities

Belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    360
  • Mass (Da)
    40,383
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    394DB1A9635D96591957B09604AE7D46
MDSKLGATLKLENGMEFRGYSFGYAGPCDGEVVFSTAMVGYPESLTDPSYSGQILCVTYPLVGNYGVPADGEDEFGISRNFESDRIHVRGLLISDYSFEYSHWKAVKSLDQWLKEQKIPGIYGIDTRELTKILREHGSMLGIIVPDGFTRDFPIEDPNLVNQVAIVSCKEVIRYGKGDKKIVLVDCGVKNNILRCLIRRGVEVIRVPWDYDFNTLEYDGLFISNGPGNPALCEKTVEHIRQAMESDRPIFGICMGNQLLCVAGGASTYKLKYGHRSHNQPVRMVGTNRCFITSQNHGFAVDNRTLGEDWEPLFINMNDGTNEGIRHKTRPFFSAQFHPEATSGPTDTEFLFDEFLSKVRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADIMJ010000003
EMBL· GenBank· DDBJ
MBO8453109.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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