A0A933X3G0 · A0A933X3G0_UNCPL
- ProteinBifunctional aspartate kinase/homoserine dehydrogenase I
- GenethrA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids845 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.
Catalytic activity
- L-aspartate + ATP = 4-phospho-L-aspartate + ADPThis reaction proceeds in the forward direction.
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartate kinase activity | |
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Biological Process | homoserine biosynthetic process | |
Biological Process | lysine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Planctomycetota
Accessions
- Primary accessionA0A933X3G0
Proteomes
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 175-208 | Disordered | |||
Compositional bias | 177-199 | Polar residues | |||
Domain | 347-416 | ACT | |||
Sequence similarities
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length845
- Mass (Da)89,832
- Last updated2023-02-22 v1
- Checksum3DE583D197590AB0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 177-199 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACRIO010000305 EMBL· GenBank· DDBJ | MBI5365012.1 EMBL· GenBank· DDBJ | Genomic DNA |