A0A931CTA2 · A0A931CTA2_9BACT

  • Protein
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • Gene
    ispG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site264[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site267[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site299[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site306[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)
Molecular Functioniron ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • EC number
  • Alternative names
    • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

Gene names

    • Name
      ispG
    • Synonyms
      gcpE
    • ORF names
      H0S81_00995

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MIC098Bin6
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfobacteria > Desulfobacterales > Desulfobacteraceae > Desulfotignum

Accessions

  • Primary accession
    A0A931CTA2

Proteomes

Family & Domains

Sequence similarities

Belongs to the IspG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    38,711
  • Last updated
    2023-02-22 v1
  • Checksum
    AB66C4D4697DE53B
MMPRRKTRQIRVGPVMVGSDAPISVQSMTNTQTRDTAATIQQIHALTSAGCEIVRVAVPEMVDALAIREIKDRITIPVIADIHFDFRLALAAAESGANGLRINPGNIGARHKVKQVADCARSHGIPIRIGVNAGSLEKEIAQRLGTTAAAMKESGLANIRILEDLGFDDIKVSLKASDVARTVEAYQLLAAETDVPFHVGVTEAGGLYAGITKSAIGIGLLLSKGLGDTIRVSLTRDPVEEIRTGYEILRALGLRQRGPEIISCPTCGRCRINLFKIAEDVEKALLERDTQIKVAIMGCVVNGPGEAKEADIGIAGADGTGILFKKGKVFKKVAQDRLVDQLLYEIDKMTKNSEDVNGSKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACCQK010000035
EMBL· GenBank· DDBJ
MBG0778495.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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