A0A930Y258 · A0A930Y258_9PROT

Function

function

Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site51L-glutamine (UniProtKB | ChEBI)
Binding site240L-glutamine (UniProtKB | ChEBI)
Binding site242L-glutamine (UniProtKB | ChEBI)
Active site268Nucleophile
Binding site269L-glutamine (UniProtKB | ChEBI)
Binding site272L-glutamine (UniProtKB | ChEBI)
Binding site310L-glutamine (UniProtKB | ChEBI)
Binding site312L-glutamine (UniProtKB | ChEBI)
Binding site313L-glutamine (UniProtKB | ChEBI)
Active site352
Active site354

GO annotations

AspectTerm
Cellular Componentcarbamoyl-phosphate synthase complex
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processarginine biosynthetic process
Biological Processglutamine metabolic process
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase small chain
  • EC number
  • Alternative names
    • Carbamoyl phosphate synthetase glutamine chain

Gene names

    • Name
      carA
    • ORF names
      ISN26_00370

Organism names

Accessions

  • Primary accession
    A0A930Y258

Proteomes

Subcellular Location

Interaction

Subunit

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-192CPSase
Domain7-137Carbamoyl-phosphate synthase small subunit N-terminal

Sequence similarities

Belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    39,659
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    9691686F19EF516BF467CA05E102D8DC
MQPIAATEAILALATGETFAGAAFGHPGPAAGELVFNTSMTGYQEIVTDPSYLGQVVCLTTAHVGVVGVNAADEEAGAPRARGLAVRALARVPSSWRAEGDLDAYCRAHGVCGIAEVDTRALAIRLREGGAVNCCVLHGGDRRGALRLARACPPMAGQALGRDAGVDEPAAWHEGAWDPGSNRHARRQGRGPKVAVLDCGAKRAILRCLRERGLRVEVLPLATPAAAIAKSFAALVVSNGPGDPGPLAEAASALKAALKAKLPVLGICLGHQLLAQACGARTAKMKFGHHGANHPVLDLRSGQVAITSQNHGFVVAAEKLPRDLELTHVSLFDRSVQGFRHRRLPALGFQGHPEASPGPREMEKVFDEFAALVRSHAAQS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADHEI010000009
EMBL· GenBank· DDBJ
MBF2734546.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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