A0A930XXJ2 · A0A930XXJ2_9GAMM

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

166350100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site206-213ATP (UniProtKB | ChEBI)
Binding site428Zn2+ (UniProtKB | ChEBI); catalytic
Active site429
Binding site432Zn2+ (UniProtKB | ChEBI); catalytic
Binding site506Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      ISN29_00730

Organism names

Accessions

  • Primary accession
    A0A930XXJ2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-25Helical
Transmembrane109-127Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain198-337AAA+ ATPase
Coiled coil571-598
Region607-663Disordered
Compositional bias630-654Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    663
  • Mass (Da)
    72,438
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    0645B0178586BB982EF2613A00658E2D
MKNLSRYLLFWVLLLGVAYFVFNMYNVSEEKPVEITYSDFISEVRLGRIDSVVFKGDGVRIYGTRSDGSEFTAVRPVYVSDPDLIVNLVDHGVRIIAEKPEEASLLSRLLVASFPVLLLLILAALFMRYSQGGSSGSGSGWRNNPLNFGRSRAKMMQGGKVDITFADVAGCEEAKEEVSELVEFLRDPSRFDNLGGRIPKGVLMVGPPGTGKTLLAKAVAGEAQVPFFSISGSDFVEMFVGVGASRVRDMFERARANSPCIVFIDEIDAVGRHRGAGVGGGHDEREQTLNQLLVEMDGFDASETVIIIAATNRPDVLDPALLRPGRFDRQVVVNLPDVRGREQILKVHSRKIKLHEDVNLAVIARGTPGFSGADLANLVNEAALMAARNKGARVQMRWFESAKDRILMGAERRSMAMTDEEKQLTAYHESGHAIVGRLCEGHDPVYKVSIIPRGRALGVTMFLPERDATTHSRKQLISRITSLYGGRVAEEIIYGEDSVTTGASNDIQRATELARNMVTRWGLSDLGPLEYDHGDDQVFLGRSAAAGGSHQSDAQAAAVDTEIRKIAESCYARARAMLAENRDKLEAMTEALMQYETLDSDQIDDVMAGVPVRPPPEPDPIFKVFGEEGDQSQRSGEEGDPGSDESDSDTREKTPPPTGEPAG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias630-654Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADHEJ010000013
EMBL· GenBank· DDBJ
MBF2753773.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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