A0A930UM09 · A0A930UM09_9GAMM

Function

function

Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site199-202ATP (UniProtKB | ChEBI)
Active site271

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological Processbiosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      hldE
    • ORF names
      ISN29_10685

Organism names

Accessions

  • Primary accession
    A0A930UM09

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-326Ribokinase
Domain44-310Carbohydrate kinase PfkB
Domain352-451Cytidyltransferase-like
Region352-484Cytidylyltransferase

Sequence similarities

In the C-terminal section; belongs to the cytidylyltransferase family.
In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    484
  • Mass (Da)
    52,512
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    5C437589DBD86CA70D414B1F6F4EB808
MPIIPNFSEVRVLVVGDLMLDRYIRGTVRRISPEAPVPVLHLPNKSKPDDRLGGAGNVAANIAAVGARCTLCAITGNDEPAEALNRLLQNANIERHLIATEACPTILKQRITDKHNEQQLLRIDVEEAFRPELSRQVGERVIALLERSDVVVLSDYGKGTLGCVETIIQAARKRGLPVLVDPKGEDFTRYTGATLITPNQSEFDAIVANHSNATELPQQGEDVRCALQLDALLITQGEDGMTLFQAEDRGGMRQFPSEAREIVFDVVGAGDTVIATLAASLGTGEQSLENCARLANYAASIAVSQHGTVPVSREKLIKRVHRRSSHAMPIIPLVDLLQVLHSPLNSGKKIVFTNGCFDLLHAGHSAYLEEAATLGDVLIVALNSDESVRRLKGPERPVNSLANRARVIGALKSVDYVIAYDDDTPEALLAEIRPHVLVKGGDYDDVKQVVGHQIVQKNGGEVKVLQIVDGLSTSNLIKDIKKQK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADHEJ010000109
EMBL· GenBank· DDBJ
MBF2755704.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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