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A0A928JVS4 · A0A928JVS4_9FIRM

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site70Proton acceptor
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site151-154substrate
Binding site172substrate
Binding site177-178substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      E7570_01650

Organism names

Accessions

  • Primary accession
    A0A928JVS4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    21,487
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    DC72E4E9F08D2A1D396CF18D587748D2
MDFILASNNKKKLGEMQRILSPLGINVVTAKMLGITLEDVVEDADTFEGNAKIKAHAACKATNMPAIADDSGICVDFLGGAPGVYSARFSGGDDEDNNNLLLEKLSGVPMEQRGAHYACAICCVFPDGREINVQGECYGYIGFERDGSEGFGYDPLFLVDGKSFGRYTAEEKDKISHRGNALRKLVAELKKTINLTPSP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SVQE01000007
EMBL· GenBank· DDBJ
MBE6740985.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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