A0A927P747 · A0A927P747_9FIRM

  • Protein
    Multifunctional fusion protein
  • Gene
    pgk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-25substrate
Binding site39substrate
Binding site62-65substrate
Binding site121substrate
Binding site154substrate
Binding site204ATP (UniProtKB | ChEBI)
Binding site295ATP (UniProtKB | ChEBI)
Binding site326ATP (UniProtKB | ChEBI)
Binding site352-355ATP (UniProtKB | ChEBI)
Binding site408-410substrate
Active site493Electrophile
Active site565Proton acceptor
Binding site571substrate
Binding site611substrate
Binding site632-633substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionADP binding
Molecular FunctionATP binding
Molecular Functionphosphoglycerate kinase activity
Molecular Functiontriose-phosphate isomerase activity
Biological Processgluconeogenesis
Biological Processglycolytic process
Biological Processphosphorylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Triosephosphate isomerase
  • EC number
  • Short names
    TIM
    ; TPI
  • Alternative names
    • Triose-phosphate isomerase
  • Recommended name
    Phosphoglycerate kinase
  • EC number

Gene names

    • Name
      pgk
    • Synonyms
      tpiA
    • ORF names
      E7337_11170

Organism names

Accessions

  • Primary accession
    A0A927P747

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.
Monomer.

Family & Domains

Sequence similarities

Belongs to the phosphoglycerate kinase family.
Belongs to the triosephosphate isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    647
  • Mass (Da)
    69,238
  • Last updated
    2023-02-22 v1
  • Checksum
    1043B9E1F38EC5AF
MNLNKMTIEDIQVTGKKVLVRCDFNVPLDAEKNITDETRINAALPTIKYLLENGAAVILCSHLGRPKGEFNMKYSLAPVAQRLSEKLGFEVKLAKDVIGEDAKRLAAEVEPGKAILLENVRFHAEEEKNDPDFAKELASMAEIYVSDAFGTVHRAHASTAGVAAYLPAVAGFLIGKELEFLGNAVENPVRPFVAILGGAKVKDKIGVIKSLLNKVDTLVIGGGMSYTFQVALGGKVGRSLLDEERIGLAKELIELAESKGVKLLLPVDNVCGDDFSNDCERITAHSRNIPDAFEGMDIGPETVALFTEEVKKARTIVWNGPMGCFEMPNFAKGTLAIAQAMAESHATTIIGGGDSAAAVTQMGLADRMSHISTGGGASLEFLEGKELPGVVCLQERIVPERRPIIAGNWKMNKTPEEAAQLVTDLIPMVKNAKCDVVVCTPAVCFGAVKPIIEGTNIKLGAQNVHFAASGAYTGELSADMLKAAGCEYVIVGHSERRQYFGETDKTVNARTIAAVRAGLKVIVCIGEMKDEREAGYTDMIVTYQTQMALHGLHANELENIVLAYEPVWAIGTGLTATDEQANETIGVVRKAVADKFGRFAAENIRIQYGGSMKGSNVKGLMAQPEIDGGLIGGASLKAADFAQVVNF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SVHE01000149
EMBL· GenBank· DDBJ
MBE5774478.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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