A0A927JCB1 · A0A927JCB1_9ACTN
- Proteinassimilatory sulfite reductase (ferredoxin)
- GenenirB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids843 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.
Catalytic activity
- 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H+ + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [4Fe-4S] cluster per subunit.
Note: Binds 1 siroheme per subunit.
Pathway
Nitrogen metabolism; nitrate reduction (assimilation).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 635 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 641 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 675 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 679 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 679 | Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | nitrate assimilation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameassimilatory sulfite reductase (ferredoxin)
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Hoyosellaceae > Lolliginicoccus
Accessions
- Primary accessionA0A927JCB1
Proteomes
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-285 | FAD/NAD(P)-binding | ||||
Sequence: NIVVVGHGMVGHRFIEALRARDEQGEWKITVLCEEPVAAYDRVALSSYVSTWDHKELALSGNDYPGDTHVEVRLGERGEAIDPEARTVTTTRGDVIHYDKLVLATGSYAFVPPVPGKDAERCFVYRTLEDLDKIRAAAEASPAGAVGVVVGGGLLGLEAANALKLMGLTPHVVELAPRLMPLQVDEGGGAQLKSLVSDLGLTIHTGVSTAAIIEQQDGTLAVELSDGSVIDASLLVFSAGVRPRDELARTSGIDVGERGGIITDLSCRTSSEDIYAIGEVA | ||||||
Domain | 322-387 | NADH-rubredoxin oxidoreductase C-terminal | ||||
Sequence: STKLKLLGVDVASFGDAFATTPGALEVVLSNPAAGTYAKIVLSDDAKTLLGGILVGDASAYATLRP | ||||||
Domain | 422-469 | BFD-like [2Fe-2S]-binding | ||||
Sequence: ICSCNAVTKGDICGAIDNGACDVASVKSCTKAGASCGGCLPLVKKLLA | ||||||
Domain | 554-615 | Nitrite/Sulfite reductase ferredoxin-like | ||||
Sequence: QKNGTYSVVPRMPGGEVTPDQLIVIGQIAKEFDLYVKVTGGQRIDMFGARVEQLPRIWQRLV | ||||||
Domain | 626-751 | Nitrite/sulphite reductase 4Fe-4S | ||||
Sequence: GKSLRTVKSCVGSSWCRYGQQDSVKMAVDLEKRYRGLRSPHKLKLAVSGCARECAEARGKDVGVIATERGWNLYVGGNGGQTPKHAVLLASDLDDETLIKYIDRYLMFYIRTADRLQRTAPWQESL |
Sequence similarities
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length843
- Mass (Da)89,207
- Last updated2023-02-22 v1
- Checksum2046D16590F77B74
Keywords
- Technical term