A0A927GNY7 · A0A927GNY7_STRGL
- ProteinGlucosamine-6-phosphate deaminase
- GenenagB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids261 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Catalytic activity
- alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4+
Activity regulation
Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
Pathway
Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 67 | Proton acceptor; for enolization step | ||||
Sequence: D | ||||||
Active site | 136 | For ring-opening step | ||||
Sequence: D | ||||||
Active site | 138 | Proton acceptor; for ring-opening step | ||||
Sequence: H | ||||||
Active site | 143 | For ring-opening step | ||||
Sequence: E | ||||||
Site | 146 | Part of the allosteric site | ||||
Sequence: S | ||||||
Site | 153 | Part of the allosteric site | ||||
Sequence: R | ||||||
Site | 155 | Part of the allosteric site | ||||
Sequence: K | ||||||
Site | 156 | Part of the allosteric site | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glucosamine-6-phosphate deaminase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | N-acetylglucosamine metabolic process | |
Biological Process | N-acetylneuraminate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucosamine-6-phosphate deaminase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A927GNY7
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-226 | Glucosamine/galactosamine-6-phosphate isomerase | ||||
Sequence: AGGELIAEAIAALLDRKPDALLGVATGSTPLPIYRALAAKVASGAVDASRARICQLDEYVGLPAGHPESYRSVVLREVVEPLGLSEASFMGPDGSAEDVQAACEAYDKALAEAGGVDLQLLGIGTDGHIGFNEPCSSLASRTRIKTLTEQTRVDNARFFDDDIEQVPHHVITQGIGTILDARHPILLATGEGKAEAVAQTVEGPVASIVPASALQL |
Sequence similarities
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length261
- Mass (Da)27,222
- Last updated2023-02-22 v1
- Checksum82ED5357A2D64131