A0A927BWH6 · A0A927BWH6_9BACL
- ProteinCobyric acid synthase
- GenecobQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1034 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
Catalytic activity
- O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 816 | Nucleophile | |||
Active site | 958 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ABC-type vitamin B12 transporter activity | |
Molecular Function | catalytic activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | glutamine metabolic process |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCobyric acid synthase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus
Accessions
- Primary accessionA0A927BWH6
Proteomes
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 25-350 | Aminotransferase class I/classII large | |||
Region | 361-454 | Disordered | |||
Compositional bias | 399-413 | Polar residues | |||
Domain | 457-684 | CobQ/CobB/MinD/ParA nucleotide binding | |||
Region | 694-729 | Disordered | |||
Domain | 737-964 | CobB/CobQ-like glutamine amidotransferase | |||
Region | 919-944 | Disordered | |||
Sequence similarities
Belongs to the CobB/CobQ family. CobQ subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,034
- Mass (Da)110,386
- Last updated2023-02-22 v1
- Checksum25B6EDEEC08EA1DA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 399-413 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACXIZ010000027 EMBL· GenBank· DDBJ | MBD2846784.1 EMBL· GenBank· DDBJ | Genomic DNA |