A0A927BWH6 · A0A927BWH6_9BACL

  • Protein
    Cobyric acid synthase
  • Gene
    cobQ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site816Nucleophile
Active site958

GO annotations

AspectTerm
Molecular FunctionABC-type vitamin B12 transporter activity
Molecular Functioncatalytic activity
Molecular Functionpyridoxal phosphate binding
Biological Processcobalamin biosynthetic process
Biological Processglutamine metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cobyric acid synthase

Gene names

    • Name
      cobQ
    • ORF names
      IDH44_16430

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IB182496
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A927BWH6

Proteomes

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain25-350Aminotransferase class I/classII large
Region361-454Disordered
Compositional bias399-413Polar residues
Domain457-684CobQ/CobB/MinD/ParA nucleotide binding
Region694-729Disordered
Domain737-964CobB/CobQ-like glutamine amidotransferase
Region919-944Disordered

Sequence similarities

Belongs to the CobB/CobQ family. CobQ subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,034
  • Mass (Da)
    110,386
  • Last updated
    2023-02-22 v1
  • Checksum
    25B6EDEEC08EA1DA
MLERYGHGGDLLSASEAFGLPPESYVDFSSNMNPLGPPQGVRDVLARYAAHIHAYPDPAVRELRLRLAERHGVDEACILVGNGAAELIDLAVRWRRPAAVGLAVPCFAEYEEAARKCGADLVRVTLNEAADFTAERAVLEAQRPGLWLLGSPNNPTGRLLPRDIPLALAASGATVVVDEAFIDFVPEESRISLAREAAGDPSLLVLRSMTKYYAIPGIRLGYAIGHPETIAALRELQVPWSVNSLAQQIGCAVLEDDEYAHRTRRWLAEERLRLEAGLNGLGLRVVPSAANYVLAELPGALGLTAAALQRQLGPRGLLIRDGGRFDGLGPRWLRVAVRLRTDNERLLDALAAALAPLGATGAASAPGGTPVGAPANGSARRWCAAPSGPGRAADCVSTAPSGPGSTGDLVSTAQPAQGRAADPVSAAQPGPAPAANRASGAEGSASEAKPKQPARTLMIQGTASDAGKSLLVTALCRSFARRGRRTAPFKAQNMSNNSYVTWDGKEIGRAQGMQAEACGILADTDMNPILLKPTREMSAQVVVHGVALRDYEARAYREQFLAEAGTIVTGALRRLRMRCDVVVLEGAGSPAEINLKDRDIVNMQAAAWADAPVLLVADIDRGGALAALVGTLELLEPHERDRVAGLIINKFRGDVSLLRPGLDWLERRTGKPVLGVVPYLPGLALESEDTLSLEAAQREAERAGSRGAVPAAEASTQQAGEEARSGQQEHSEHALLDIAVLRLPHLSNFTDFDPLRFEPDVRLRYVEDARRLGEPDALVLPGSKNVMDDLLHLRASGLAEAVLHYAARGGHIVGICGGYEMLGRRLCDPDHAESVHDELDGLGLLPLEVRFAHPKRTVRMFGTARLPGWTAPEEVEGYEIHTGQMRVEPGAGRPLRVRPADVGHAPLGVAQPDTAAAAGSAARPPADERTASVAARDSVEADEGACTPDGRIWGTFLHGVLHGDAFRRRWLNGLRAAKGYAPLPVQLHFRRLREAEFDRLADHIEAHCDMARIEALLQGEAIITNNAVRKGEGR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias399-413Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACXIZ010000027
EMBL· GenBank· DDBJ
MBD2846784.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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