A0A927BNU2 · A0A927BNU2_STRGL

Function

function

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Cleavage of peptide bonds with very broad specificity.
    EC:3.4.25.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

Pathway

Protein degradation; proteasomal Pup-dependent pathway.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site54Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentproteasome core complex, beta-subunit complex
Molecular Functionthreonine-type endopeptidase activity
Biological Processmodification-dependent protein catabolic process
Biological Processproteasomal protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Proteasome subunit beta
  • EC number
  • Alternative names
    • 20S proteasome beta subunit
    • Proteasome core protein PrcB

Gene names

    • Name
      prcB
    • ORF names
      ID875_22960

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • QF2
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A927BNU2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for propeptide, chain.

TypeIDPosition(s)Description
PropeptidePRO_50381960421-53Removed in mature form; by autocatalysis
ChainPRO_503819604154-281Proteasome subunit beta

Keywords

Interaction

Subunit

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.

Family & Domains

Sequence similarities

Belongs to the peptidase T1B family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    30,174
  • Last updated
    2023-02-22 v1
  • Checksum
    BA6463C8407C28D7
MEANTRSTGRLPAAFLTPGSSSFMDFLSDHSPEMLPGKRSLPPLQGAVEAPHGTTIVAASFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGAQLSLEGKANRLSTMIRSNLAMAMQGLAVVPLFAGYDVDRDKGRIFSYDVTGGRSEENGYAATGSGSIFARGSMKKLYREDLTEQQALTLVVQALYDAADDDSATGGPDVARRIYPIVTVITDEGFRRLTDQESSEIARAVLERRLEEPDGPRAALL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACWUS010000007
EMBL· GenBank· DDBJ
MBD2830051.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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