A0A927BM45 · A0A927BM45_STRGL

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site11-16NAD+ (UniProtKB | ChEBI)
Binding site14NADPH (UniProtKB | ChEBI)
Binding site15NADPH (UniProtKB | ChEBI)
Binding site35NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site52NADPH (UniProtKB | ChEBI)
Binding site109NADPH (UniProtKB | ChEBI)
Binding site109sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site109substrate
Binding site139sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site143NAD+ (UniProtKB | ChEBI)
Binding site143NADPH (UniProtKB | ChEBI)
Active site194Proton acceptor
Binding site194sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site247sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site257sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258NAD+ (UniProtKB | ChEBI)
Binding site258NADPH (UniProtKB | ChEBI)
Binding site258sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258-259substrate
Binding site259sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site284NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      ID875_20185

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • QF2
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A927BM45

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-163Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain183-323Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    336
  • Mass (Da)
    35,024
  • Last updated
    2023-02-22 v1
  • Checksum
    74808DCFF0130FB2
MTHPAKVAVFGTGSWGTAFAVILADAGCEVTLWGRRPELAEAVNTTHTNPDYLPGIALPETIRATTDAAEALRGAEFAFLVVPSQTLRANLADWAPHLEPETVLVSLMKGVELGTAELMSEVIADVTEVSADRIAVVSGPNLAKEIAERRPAAAVVACADESVAQRLQAACHTAYFRPYTNTDVVGCELGGAVKNVIGLAVGIADGMGLGDNTKGSLITRGLAETTRLGVAMGADPLTFSGLAGLGDLVATCSSPLSRNHTFGTNLGRGMTLQETIAVTKQTAEGVKSCESVLALARRHGVDMPITETVVSIVHEGKSPVVAVKELMSRSAKAERR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACWUS010000004
EMBL· GenBank· DDBJ
MBD2829764.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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