A0A926V971 · A0A926V971_9CYAN
- ProteinOrotate phosphoribosyltransferase
- GenepyrE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids477 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Catalytic activity
- H+ + orotidine 5'-phosphate = CO2 + UMP
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 373 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: R | ||||||
Binding site | 374 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: K | ||||||
Binding site | 377 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: K | ||||||
Binding site | 379 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: H | ||||||
Binding site | 399-407 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: DDILISGKS |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | orotate phosphoribosyltransferase activity | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | pyrimidine ribonucleotide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotate phosphoribosyltransferase
- EC number
- Short namesOPRT ; OPRTase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Oscillatoriophycideae > Oscillatoriales > Aerosakkonemataceae > Aerosakkonema
Accessions
- Primary accessionA0A926V971
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-173 | Orotidine 5'-phosphate decarboxylase | ||||
Sequence: DLSQLWEWLDTIIAQTSDLVCAYKPILGFYQALGAPGLKLLEQTLQRIPKHIPIILDAKHSDIYTSTVFAKTAFERWGVDAVTVNTYAGWDHVAPFLLYPGKAVFVLCANANPSAAALQEFPTPSQPFYLHLIDEAKN | ||||||
Domain | 341-439 | Phosphoribosyltransferase | ||||
Sequence: GLEFDRIAGIPYGSLPTATGLSLRLERPMVFPRKEVKAHGTQKVIEGNFQPGETVVVVDDILISGKSAIEGAGKLQSVGLKVEDIVVFIDHEKGVKDRL |
Sequence similarities
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length477
- Mass (Da)52,989
- Last updated2023-02-22 v1
- Checksum35CD8798588F9511
Keywords
- Technical term