A0A926V971 · A0A926V971_9CYAN

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site3735-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3745-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site3775-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3795-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site399-4075-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processpyrimidine ribonucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      H6G03_00090

Organism names

  • Taxonomic identifier
  • Strain
    • FACHB-1375
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Oscillatoriophycideae > Oscillatoriales > Aerosakkonemataceae > Aerosakkonema

Accessions

  • Primary accession
    A0A926V971

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-173Orotidine 5'-phosphate decarboxylase
Domain341-439Phosphoribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    52,989
  • Last updated
    2023-02-22 v1
  • Checksum
    35CD8798588F9511
MQFFDKLLYAIERNQSLLYVGLDPDLDEVVIGEGEDLSQLWEWLDTIIAQTSDLVCAYKPILGFYQALGAPGLKLLEQTLQRIPKHIPIILDAKHSDIYTSTVFAKTAFERWGVDAVTVNTYAGWDHVAPFLLYPGKAVFVLCANANPSAAALQEFPTPSQPFYLHLIDEAKNWGTPEQLGLKVGGTPEILARIRAAAPERLILLQEDYTGDRDLNAILAAGLDKQGEGLLLPVPPNIIEEPGHDIAAAVRDLRDKVNEERMRIVQANPTCDVWLPNVCSLQSEPHRDLILQLYDIGCIIFGEHKQASGAIFPYYIDLRKIISQPQIFHQVLTAYAGILKGLEFDRIAGIPYGSLPTATGLSLRLERPMVFPRKEVKAHGTQKVIEGNFQPGETVVVVDDILISGKSAIEGAGKLQSVGLKVEDIVVFIDHEKGVKDRLKEQGFRAHSALTITEIAETLYNAGRVDEEQFKLLMWEH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACJPW010000001
EMBL· GenBank· DDBJ
MBD2179531.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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