A0A926NU52 · A0A926NU52_9HYPH

  • Protein
    Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ
  • Gene
    msrQ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionelectron transfer activity
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on diphenols and related substances as donors
Biological Processprotein repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ
  • Alternative names
    • Flavocytochrome MsrQ

Gene names

    • Name
      msrQ
    • ORF names
      HK439_09510

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PHM038
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Stappiaceae > Roseibium

Accessions

  • Primary accession
    A0A926NU52

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane28-50Helical
Transmembrane65-83Helical
Transmembrane95-113Helical
Transmembrane125-150Helical
Transmembrane162-180Helical
Transmembrane186-205Helical
Transmembrane217-239Helical
Transmembrane259-282Helical

Keywords

Interaction

Subunit

Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain63-174Ferric oxidoreductase

Sequence similarities

Belongs to the MsrQ family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    32,128
  • Last updated
    2023-02-22 v1
  • Checksum
    BB2F11020A04F932
MQGMTVASTPLRFAPWTDRKGQLSPLRLAVFIGLLVPAVAIFADLIFGPMRPEPFKYALLESGRWVVRFLLLSLAITPFRRILGWNRLIGVRRMIGVSVLCYALLHLGFYAAQENWHLGKVASEIVLRVYLTIGFAALLGLIALGATSFDAAVRRMGRNWNLLHRLAYVIGVLALIHFFMQAKSDVTEPTLMAGLFILLMSYRVAGIAKLDISRSWVLGLCAAISAALTAGVEYSWYAIATGIPPKLVFLANFDLETAIRPAVWVAIIGIAVASLPLLRMLLGGIVQLRPAKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABFCZ010000009
EMBL· GenBank· DDBJ
MBD1546499.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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