A0A926JUD0 · A0A926JUD0_9FLAO
- ProteinDihydroorotate dehydrogenase (quinone)
- GenepyrD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids344 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + a quinone = a quinol + orotate
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 67-71 | FMN (UniProtKB | ChEBI) | ||||
Sequence: AGFDK | ||||||
Binding site | 71 | substrate | ||||
Sequence: K | ||||||
Binding site | 91 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 116-120 | substrate | ||||
Sequence: NRMGF | ||||||
Binding site | 149 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 182 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 182 | substrate | ||||
Sequence: N | ||||||
Active site | 185 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 187 | substrate | ||||
Sequence: N | ||||||
Binding site | 223 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 251 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 252-253 | substrate | ||||
Sequence: NT | ||||||
Binding site | 273 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 302 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 323-324 | FMN (UniProtKB | ChEBI) | ||||
Sequence: YT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | dihydroorotate dehydrogenase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (quinone)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Sinomicrobium
Accessions
- Primary accessionA0A926JUD0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-342 | Dihydroorotate dehydrogenase catalytic | ||||
Sequence: LEREVLGLKFKNPVGLAAGFDKDARLFNELSGFGFGFIEIGTLTPKPQPGNPRKRLFRLKEDTAIVNRMGFNNGGVEEAVKRLKKPSASLRARGILIGGNIGKNKVTPNENATDDYRKCFEALHSHVDYFVVNVSSPNTPNLRALQDKEPLTKLLSGLQNHKLQTANHKPIMLKIAPDLTEGQLRDIVRIVKDTGIAGIIATNTTISREGLASPVKKETGGLSGKPLKDRSTEVIRFLHRESGGSFPIIGVGGVHSPEDALEKLEAGASLVQVYTGFIYEGPGLVKRINKALL |
Sequence similarities
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length344
- Mass (Da)37,910
- Last updated2023-02-22 v1
- Checksum686DEB05187B339E
Keywords
- Technical term