A0A926JUD0 · A0A926JUD0_9FLAO

  • Protein
    Dihydroorotate dehydrogenase (quinone)
  • Gene
    pyrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site67-71FMN (UniProtKB | ChEBI)
Binding site71substrate
Binding site91FMN (UniProtKB | ChEBI)
Binding site116-120substrate
Binding site149FMN (UniProtKB | ChEBI)
Binding site182FMN (UniProtKB | ChEBI)
Binding site182substrate
Active site185Nucleophile
Binding site187substrate
Binding site223FMN (UniProtKB | ChEBI)
Binding site251FMN (UniProtKB | ChEBI)
Binding site252-253substrate
Binding site273FMN (UniProtKB | ChEBI)
Binding site302FMN (UniProtKB | ChEBI)
Binding site323-324FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessUMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      IBL28_15410

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FJxs
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Sinomicrobium

Accessions

  • Primary accession
    A0A926JUD0

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-342Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    344
  • Mass (Da)
    37,910
  • Last updated
    2023-02-22 v1
  • Checksum
    686DEB05187B339E
MYKTLIRPILFQFDPEKVHHFTFAFIKAANKIPGISALIRRMYTVNDPRLEREVLGLKFKNPVGLAAGFDKDARLFNELSGFGFGFIEIGTLTPKPQPGNPRKRLFRLKEDTAIVNRMGFNNGGVEEAVKRLKKPSASLRARGILIGGNIGKNKVTPNENATDDYRKCFEALHSHVDYFVVNVSSPNTPNLRALQDKEPLTKLLSGLQNHKLQTANHKPIMLKIAPDLTEGQLRDIVRIVKDTGIAGIIATNTTISREGLASPVKKETGGLSGKPLKDRSTEVIRFLHRESGGSFPIIGVGGVHSPEDALEKLEAGASLVQVYTGFIYEGPGLVKRINKALLDR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACVDC010000056
EMBL· GenBank· DDBJ
MBC9797361.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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