A0A926GFR0 · A0A926GFR0_9RHOB

  • Protein
    dITP/XTP pyrophosphatase
  • Gene
    rdgB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-18substrate
Active site74Proton acceptor
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75substrate
Binding site160-163substrate
Binding site183substrate
Binding site188-189substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      H4P12_05885

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 11-3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Paracoccus

Accessions

  • Primary accession
    A0A926GFR0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    202
  • Mass (Da)
    21,773
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    CFE390744CD3C9430BB4E10A378D9594
MRKFTQNKLLIATHNAGKLAEMRALLEPRGIEVVGAAEMGLGEPVETEDNFIGNARIKARAAVTATGLPALSDDSGISVDALNGAPGVYTADWAETGNGRDFPMAMQRTWDELEAVNAPAPRTAQFRCTLVLMWPDGHDEVFEGVLPGQVVWPPRGTEGHGYDPIFMPEGADITLGEMSAEQKNRLSHRARAVAKMLEGSFA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACOQL010000002
EMBL· GenBank· DDBJ
MBC9246252.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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