A0A923G3X9 · A0A923G3X9_9PSED

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site239pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site273-276pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site276substrate
Binding site312substrate
Binding site316substrate
Active site342Proton donor
Binding site343substrate
Binding site370pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site370substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      HU751_01640

Organism names

  • Taxonomic identifier
  • Strain
    • BW13M1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A923G3X9

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue60N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-280Orn/DAP/Arg decarboxylase 2 N-terminal
Domain281-368Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    45,198
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    BCB194F34FC4EC7F348B76880AA6CD61
MDAFNYRGGELFAEGVALTAIAERFGTPTYVYSRAHIEAQYRSYTDALQGVEHLVCFAVKANSNLGVLNLLARLGAGFDIVSGGELERVLAAGGRADRVVFSGVGKTREDMRRALEVGVHCFNVESTDELERLQVVAAEMGKTAPVSLRVNPDVDAGTHPYISTGLKENKFGIAIADAEAIYVRAAQLPNLDVVGVDCHIGSQLTTVEPFLDALDRLLVLVDRLAECGIHLRHLDLGGGVGVRYRDEQPPLLADYIAAIRERVGERDLALVFEPGRYIVANGGVLLTRVEYLKHTEHKDFAIIDAAMNDLIRPALYQAWMDVSAVKPREGEGRAYDLVGPICETGDFLGKDRVLDLAEGDLLAVRSAGAYGFVMSSNYNTRGRCAEVLVDGDQAFEVRRRETVAELFAGESLLPE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABWRJ010000001
EMBL· GenBank· DDBJ
MBC3444454.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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