A0A922L014 · A0A922L014_DERFA
- ProteinTrifunctional purine biosynthetic protein adenosine-3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2015 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- N1-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H+
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type deubiquitinase activity | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoribosylamine-glycine ligase activity | |
Molecular Function | phosphoribosylformylglycinamidine cyclo-ligase activity | |
Molecular Function | phosphoribosylglycinamide formyltransferase activity | |
Biological Process | 'de novo' IMP biosynthetic process | |
Biological Process | adenine biosynthetic process | |
Biological Process | protein deubiquitination | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTrifunctional purine biosynthetic protein adenosine-3
Including 3 domains:
- Recommended namePhosphoribosylamine--glycine ligase
- EC number
- Alternative names
- Recommended namePhosphoribosylformylglycinamidine cyclo-ligase
- EC number
- Alternative names
- Recommended namePhosphoribosylglycinamide formyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922L014
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 112-317 | ATP-grasp | ||||
Sequence: KNFMKKYNIPTAAFENFTDHERAKEYVRSKGALVIKASGLAAGKGVIVAKTVDEACEAIDDMMLRKKFGKAGNEIVVEEFLEGDEVSVFAMTDGVNHRILLPAQDHKRAYDNDEGPNTGGMGAYCPYPFLNDEQLDIIKENIIQKTIDGMHQEGHPFVGLLYAGLMITPHGPKVIEFNCRFGDPETQSILSLLKSDIFDHFMACMY | ||||||
Domain | 1068-1402 | USP | ||||
Sequence: RGLKNLGATCYINTFLQLWFHNVDLRQAIYKWRPNAISNLIPTSSLSEQFLVNPITCLQLVLSMMQYSVRSVVDPTPFIKCLNLDASQEQDTHEFLSLFNSYIQNKLNHENDKSIQKTINQQYCMKIAYIIKCSKCKFVSERESDFYELLLRVKGFKDIDECIGDYLKEENLDGTNRYACQICNGLQDAKRFIELRKLPPVLNLQLLRFESSNGHSRKISSFLKFPKRLDMSKFVRPEQTNPTNANVYNLFAVLIHEGQTAYSGHYITFIKKDNLWFKFNDENVEQLKDFNLKIDNDDDFHSGQNGGNNDGTGNGRNEKGFHKSKNAYMLVYKLD |
Sequence similarities
In the C-terminal section; belongs to the GART family.
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,015
- Mass (Da)228,755
- Last updated2023-02-22 v1
- Checksum1079ED2732EFCF35
Keywords
- Technical term