A0A922L014 · A0A922L014_DERFA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylamine-glycine ligase activity
Molecular Functionphosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processadenine biosynthetic process
Biological Processprotein deubiquitination
Biological Processproteolysis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Trifunctional purine biosynthetic protein adenosine-3

Including 3 domains:

  • Recommended name
    Phosphoribosylamine--glycine ligase
  • EC number
  • Alternative names
    • Glycinamide ribonucleotide synthetase
      (GARS
      )
    • Phosphoribosylglycinamide synthetase
  • Recommended name
    Phosphoribosylformylglycinamidine cyclo-ligase
  • EC number
  • Alternative names
    • AIR synthase
      (AIRS
      )
    • Phosphoribosyl-aminoimidazole synthetase
  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • ORF names
      DERF_013041

Organism names

  • Taxonomic identifier
  • Strain
    • Derf
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922L014

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain112-317ATP-grasp
Domain1068-1402USP

Sequence similarities

In the C-terminal section; belongs to the GART family.
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,015
  • Mass (Da)
    228,755
  • Last updated
    2023-02-22 v1
  • Checksum
    1079ED2732EFCF35
MSKKVLVIGNGSREHCIAWKLSQSPKVSNIIVSPGNGGLSQCGGKISMIDLNLSNHNELIEWCRNNRIDLVVVGPEDPLSKGISDSLNSNGIVCFGPSQKAARIECDKAFAKNFMKKYNIPTAAFENFTDHERAKEYVRSKGALVIKASGLAAGKGVIVAKTVDEACEAIDDMMLRKKFGKAGNEIVVEEFLEGDEVSVFAMTDGVNHRILLPAQDHKRAYDNDEGPNTGGMGAYCPYPFLNDEQLDIIKENIIQKTIDGMHQEGHPFVGLLYAGLMITPHGPKVIEFNCRFGDPETQSILSLLKSDIFDHFMACMYGQVDEIRFEWDNRYAVGIVLASGGYPGPIVKNIEIHGLNILNQLSDVHAFYSGTALKDGDLVTSGGRIMTIVALDHSLKQAAIKARNAVSMIKIEKSFFRNDIASKAIRRLETQIDYKQSGVDINAGNQLVEHIKEFARRTTRSGVMEQIGGFGALFDVSKLGMQDPILVSGTDGVGTKLKIAIDTGILNTVGIDLVAMCVNDILVQGAEPLFFLDYFACSRLRVDKAADIIKGISDGCLQSNCALIGGETAEMPGMYVGDDFDLAGFAVGAVERRQMLPRKSSIAEGDVIIGLTSSGVHSNGFSMVRKIMEVNQVNFGDQFDEQRKFHDILLTPTKIYVKSLMPAIKTGKIKALAHITGGGLIENIPRILPKEFGVELDAMSWPMHEIFTWLKHAGNVADHELQKTFNCGLGMVLIVSAKDANAIQDQIKTSNGEESYQVGKIIRRSDRAVIVRNFAQAIERNSSKITIKRTEREKKRVAVLISGSGTNLKAIIEYVNRNAHKTCINLTMVISNKSSAPGLQFAREAGIPVEVIVKKKIQSREEYDQLLNKALDDAHIDIVCLAGFMQMLTENFVNKWMGKMINIHPSLLPAFKGMDAYGQALQYGVKFTGCTSHFVVPEMDAGPIIAQGVVDIRPGETHDSLVERGKAVEHQIYPKALELVCSGQNYFTNMDHATAATDVHNNDTFLDCMILKFYKLDIEPCKSRANRNCTNNARCLKGLGQATWLINQVEDIQEEDKNLAGEEQFCFRGLKNLGATCYINTFLQLWFHNVDLRQAIYKWRPNAISNLIPTSSLSEQFLVNPITCLQLVLSMMQYSVRSVVDPTPFIKCLNLDASQEQDTHEFLSLFNSYIQNKLNHENDKSIQKTINQQYCMKIAYIIKCSKCKFVSERESDFYELLLRVKGFKDIDECIGDYLKEENLDGTNRYACQICNGLQDAKRFIELRKLPPVLNLQLLRFESSNGHSRKISSFLKFPKRLDMSKFVRPEQTNPTNANVYNLFAVLIHEGQTAYSGHYITFIKKDNLWFKFNDENVEQLKDFNLKIDNDDDFHSGQNGGNNDGTGNGRNEKGFHKSKNAYMLVYKLDTESNRPLLNELRQSNLPDYLVDYIEKDNQKYLQEKEDLLIQKCQERLKELNHQRLVRQIFSKMELIQPQTKQCDITVSSNMNNNQNHSQLNETFDAIDKSWLMNFFRASTSDEVPAIDNKSLLCMHGKLNVDSSYKCISTESADQIYSLYKSDIRLKLPEYFCKQCIQYRMYMSRLKQTIDDDQKLIRNLGKFKNCQDENLYFVGKESMKKWKNLRIDSIKRQYEVDFKPATNFNFNEDLLCQHGQLCSDSSKRTLIRHQAWLILRKHFPGSPEFDENASPCSDCLEIDRNRQIIRDKNYDIALIQRSSLINLYNGELFRYWPDLLAGHCYHMIATKFYMAWKKFVSHPNTTPSPDSLMQYESNIICTKHSLFIFPPFDDKYVGYDKIYLILDQNEWTALTEFYNFSIDVSFIRINDSENCDQYELKPGFCSYCHQTFKQKRFIYDKLPIYVKKIVTEEANTDEDFNNNNPIKKSKIIDSNHNQQHRNDFETVQKNNQQQPQTNQRKRTLRKRRMFNELEILSSSHDKLKDIKVKIMQHFNVATYDQVLWYNGKQLLSAQNNCTIGELEIEPHTTLLLKVDDMMDENVSPVECTNVGNNGPEVGFKGTQLHLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASGP02000007
EMBL· GenBank· DDBJ
KAH9497027.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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