A0A922K330 · A0A922K330_CARIL

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site181ATP (UniProtKB | ChEBI)
Binding site245-246ATP (UniProtKB | ChEBI)
Binding site270-273ATP (UniProtKB | ChEBI)
Binding site271Mg2+ (UniProtKB | ChEBI); catalytic
Site272Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site299-301substrate
Active site301Proton acceptor
Binding site344-346substrate
Binding site400substrate
Binding site452-455substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      I3842_02G022100

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fagales > Juglandaceae > Carya

Accessions

  • Primary accession
    A0A922K330

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain174-476Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    529
  • Mass (Da)
    58,086
  • Last updated
    2023-02-22 v1
  • Checksum
    73FCBF589A980732
MDALLHSITPNFALPRRDSHPSYGLPRLNSPCRRSNSAHVAKKLLVSAATEKRGPDLDFNDPDWKSKFQKDFERRFNIPHITDIFPDAISIPSTFCLKMRTPVSEDFAGGYPSDEEWHGYINNNDRVLLKVINYTSPTSAGAVCIDPDCTWVEQWVHRAGPREKIYFRPEEVKAAILTCGGLCPGLNDVIRQIVVTLEIYGVKKIVGIPFGYRGFSDKELTEMPLSRKVVQNIHLSGGSLLGVSRGGPPISEIVDSMEERGINMLFVLGGNGTHAGANAIHNECRKRQMRVAVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGVGIVKLMGRSSGFIAMHASLASGQVDICLIPEVHFNLHGPHGILRHLKYLIETKGSAVICVAEGAGQDFLQKTNAKDASGNTVLGDIGVHIQQEIKKKFKGIGIPVDVKYIDPTYMIRCGRANASDGILCTVLGQNAVHGAFAGYSGITVGICNTHYVYLPIPEVISYPRLVDPNSRMWHRCLTSTGQPDFI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM031826
EMBL· GenBank· DDBJ
KAG6725227.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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