A0A922IG56 · A0A922IG56_DERFA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionsterol esterase activity
Molecular Functiontriglyceride lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • ORF names
      DERF_002230

Organism names

  • Taxonomic identifier
  • Strain
    • Derf
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922IG56

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain53-251Hormone-sensitive lipase N-terminal
Domain321-480Alpha/beta hydrolase fold-3

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    640
  • Mass (Da)
    74,445
  • Last updated
    2023-02-22 v1
  • Checksum
    ABE2841B9FD74CDB
MKMALNSYLCNFIQSPVGYAFDIEKARIDNDRSISDQLDQVFHTLTVIYADDVELIDYIQRIRHDVDLVLQQAPLFDLDDQTQGNGYWTLLIIMIKFGRILSTPDLKKKIGRLPLIHLMQIMVEGLKVGLQLHTPKLKSMQQIDSNGKVDLSLFTDEMDFEGILDLIQSLKVPMNSLHEHFNFCWLGSMSKVMQLFTNFMAIYSTQWKSFKIYNWLSHKARAQMFTNMVLNVNVDCLQSMWNITEFPLVRIFTPSFWNRFILENINIYAPRQRRWIIDATKPIIHDRRADPNVPYPIMKQSSIRGLLFRYRHNPKNKSLMFHLHGGGFISQSPESHACYLVKWVRKLDDIPILSVDYSLSPQVIFPEALQEILDMYLWILSKDPEVEKTFGFLPEKIVFCGDSAGGNFSMAMMLILNQIQKKIAESDEDKQKYRYPNGLFLFYAPLVVATMVSPSRILTSIDGLIPLGTLLNCLGAYLPDEIFEDNLPKEENIDYAKGKETVAYQVGGYFINKLKDVLSYLLQLKVVYRIKPWYRRTGNLKKCLDKMNTFVQNPFVSPLLAESVKDFNHIPLYLYPLTFDAFLDDSIEMAKRWQKDKVKVEILDDLPHGFLNFVEFDYKARKASYKCIDRISEILKHIDD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASGP02000001
EMBL· GenBank· DDBJ
KAH9528273.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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