A0A922IDB1 · A0A922IDB1_DERFA
- ProteinPhosphoinositide phospholipase C
- GenePLCE1_1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids4140 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
- an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell presynaptic membrane | |
Cellular Component | other organism cell membrane | |
Cellular Component | plasma membrane | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | lyase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Molecular Function | toxin activity | |
Biological Process | exocytosis | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol | |
Biological Process | small GTPase-mediated signal transduction | |
Biological Process | system development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoinositide phospholipase C
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922IDB1
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 136-157 | Disordered | ||||
Sequence: SLDKTSLTGKKPSSSSSSFQKD | ||||||
Repeat | 358-386 | ANK | ||||
Sequence: PIFLAVALNNSVILRELISYGADVNLMDG | ||||||
Repeat | 387-421 | ANK | ||||
Sequence: HGVTPLHLCLCQQHISRACLRLLIHSGAKLRTKNN | ||||||
Region | 904-934 | Disordered | ||||
Sequence: MQKNPSNNNKNHDKSHHSKSETEKDSIEQPS | ||||||
Compositional bias | 912-929 | Basic and acidic residues | ||||
Sequence: NKNHDKSHHSKSETEKDS | ||||||
Region | 1576-1601 | Disordered | ||||
Sequence: ISQTQQQQQQQQEKNQPPCSTSSLSR | ||||||
Compositional bias | 1859-1873 | Polar residues | ||||
Sequence: GKSASIPASSAMSSS | ||||||
Region | 1859-1891 | Disordered | ||||
Sequence: GKSASIPASSAMSSSFDENDEEENDQNATTNKA | ||||||
Domain | 2167-2458 | Ras-GEF | ||||
Sequence: FPEEVALCLAQVEYDLFYNIQPVHYIRQVTLDLSAQISSTGEDDSQNKQSVDNDGMPTALTVEDLIERFHEVSSWITQLIISQPTHEMRKAFLSCIMRVVQTCWNMGNFNSAVEILAGLKSEKLKPFWLSIEQKDDLHLCHKLSKILLTLNEPSDEYKEAVIKALDIPHSQVIPFFGAFLFDLKNVLKRLPSLIVLLNEHANNYRDSIESNHHQPRIETISDFNGDNNYMSRIGVGGIINMEKMYKAHQVMDNLRTFHIHSIRRNQLLTTINQTSNITSNESAMLAINANET | ||||||
Region | 3288-3346 | Disordered | ||||
Sequence: SLVSNTSTGSFNDDDDDEYDDEDDDEDVEELLPMSLSTSIGTSPEKRTGLSEKDTPRIQ | ||||||
Compositional bias | 3298-3318 | Acidic residues | ||||
Sequence: FNDDDDDEYDDEDDDEDVEEL | ||||||
Domain | 3491-3582 | PI-PLC Y-box | ||||
Sequence: YQVASINENTAKKLCRKNPLTVIAHTESQIMRTYPTGMRIDSSNFNPVIFWAFGIQNVALNYQTVDTALQIYSAMFEQNGGCGYVLKSRVMR | ||||||
Domain | 3586-3718 | C2 | ||||
Sequence: HMMYGRFNPWDKEFDGLHTINLTITIISGQYVCPNTNTGSPQVEVETIGIPVDCNRQRTKIVQRNSLNPIWNDTFRFRIKFVDLVFLRITVTDVTLNQMVAQITLPVKCLRQGYRHLRLRSILNQNQPLSTLF | ||||||
Domain | 3782-3870 | Ras-associating | ||||
Sequence: PEESSTILKITQDSTVNDVIAQALYKANKPNESVNDYVLLEEVNKGWEKNRPSDRSALTQRILDPNERPLEAQNNWKGDGKFILKRLAD | ||||||
Domain | 3923-4013 | Ras-associating | ||||
Sequence: DQPYTILKSLVTSTAQNIITQALHKAHRSEDSKKFVLVEEIENFIDTQLNEPKLNKNCISYRRVLEDDENIYNVQTQWKNKGKFELKYRSD | ||||||
Region | 4055-4123 | Disordered | ||||
Sequence: KHFHRKESDDSLQRSTNQSNQEKPVTNPNIITMNNQSRQVHSDGELSSDIDERTGSSTMNETNMSSFSR | ||||||
Compositional bias | 4067-4097 | Polar residues | ||||
Sequence: QRSTNQSNQEKPVTNPNIITMNNQSRQVHSD | ||||||
Compositional bias | 4105-4123 | Polar residues | ||||
Sequence: DERTGSSTMNETNMSSFSR |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length4,140
- Mass (Da)471,293
- Last updated2023-02-22 v1
- Checksum910C914AD3EC65B2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 912-929 | Basic and acidic residues | ||||
Sequence: NKNHDKSHHSKSETEKDS | ||||||
Compositional bias | 1859-1873 | Polar residues | ||||
Sequence: GKSASIPASSAMSSS | ||||||
Compositional bias | 3298-3318 | Acidic residues | ||||
Sequence: FNDDDDDEYDDEDDDEDVEEL | ||||||
Compositional bias | 4067-4097 | Polar residues | ||||
Sequence: QRSTNQSNQEKPVTNPNIITMNNQSRQVHSD | ||||||
Compositional bias | 4105-4123 | Polar residues | ||||
Sequence: DERTGSSTMNETNMSSFSR |
Keywords
- Technical term