A0A922I488 · A0A922I488_DERFA

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site56-59CoA (UniProtKB | ChEBI)
Binding site82CoA (UniProtKB | ChEBI)
Binding site135-137CoA (UniProtKB | ChEBI)
Binding site199substrate; ligand shared with subunit beta
Active site291Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      SUCLG1
    • ORF names
      DERF_005542
      , HUG17_3476

Organism names

  • Taxonomic identifier
  • Strains
    • Derf
    • JKM2019
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922I488

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-139CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    338
  • Mass (Da)
    35,733
  • Last updated
    2023-02-22 v1
  • Checksum
    1B3F7D0F34939C29
MVIQVNNILRQLSVSRLTSIKTNSYINHQIIRNDYTSTRNALKIGSHTKVICQGFTGKQGTFHSKQAIEYGTKMVGGVSPSKAGQIHLDLPVFKTVKEARDKTGADATVIYVPAPGAASAIMEALDAEIPLIVCITEGIPQLDMVKVKHRLVRQDKSRLIGPNCPGIIKPGECKIGIMPGHIHTPGKIGIVSRSGTLTYEAVHQTTEVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDPETKGIILIGEIGGNAEELAAEYLKNNNSGPNGKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAQDKIDALESAGVRVTRSPAQMGSSLLEEMKKRGLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SDOV01000007
EMBL· GenBank· DDBJ
KAH7639443.1
EMBL· GenBank· DDBJ
Genomic DNA
ASGP02000002
EMBL· GenBank· DDBJ
KAH9521929.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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