A0A922I3Q8 · A0A922I3Q8_DERFA
- ProteinMethylthioribose-1-phosphate isomerase
- GeneMRI1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids892 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Catalytic activity
- S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 171 | Transition state stabilizer | ||||
Sequence: C | ||||||
Active site | 251 | Proton donor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | S-methyl-5-thioribose-1-phosphate isomerase activity | |
Biological Process | L-methionine salvage from S-adenosylmethionine | |
Biological Process | mRNA splicing, via spliceosome |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylthioribose-1-phosphate isomerase
- EC number
- Short namesM1Pi ; MTR-1-P isomerase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922I3Q8
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 346-414 | Disordered | ||||
Sequence: RDMDSIQTTPVRSRHQHIATPHRPAIRGPPTIKSSTPIQQHQKQSSSSSSQEQQQQQTNDNDGETMVWD | ||||||
Compositional bias | 377-410 | Polar residues | ||||
Sequence: IKSSTPIQQHQKQSSSSSSQEQQQQQTNDNDGET | ||||||
Repeat | 578-619 | WD | ||||
Sequence: ISGHTGWIRCIAVEPGNEWFATGSNDRIIKIWDLASGTLKLS | ||||||
Repeat | 620-661 | WD | ||||
Sequence: LTGHISPVRGLEVSPRQPYLFSCGEDKMVKCWDLEYNKVVRH | ||||||
Repeat | 662-703 | WD | ||||
Sequence: YHGHLSGVYCLSLHPTLDILVTGGRDSVARVWDMRTKAQIHS | ||||||
Repeat | 704-745 | WD | ||||
Sequence: LGGHSNTVASVFCQATDPQVVTGSHDSTIRLWDIVAGKTMAT | ||||||
Repeat | 787-827 | WD | ||||
Sequence: LNGHDSMINALAVNDDNVLVSGGDNGSMFFWDWRTGYNFQR |
Sequence similarities
Belongs to the WD repeat PRL1/PRL2 family.
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length892
- Mass (Da)100,186
- Last updated2023-02-22 v1
- ChecksumB815E059D0700989
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 377-410 | Polar residues | ||||
Sequence: IKSSTPIQQHQKQSSSSSSQEQQQQQTNDNDGET |
Keywords
- Technical term