A0A922I3N2 · A0A922I3N2_DERFA
- ProteinAldose 1-epimerase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids369 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Catalytic activity
- alpha-D-galactose = beta-D-galactoseThis reaction proceeds in the backward direction.
Pathway
Carbohydrate metabolism; galactose metabolism.
Carbohydrate metabolism; hexose metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 81-82 | beta-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: NR | ||||||
Active site | 185 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 185-187 | beta-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: HSY | ||||||
Binding site | 252 | beta-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 331 | Proton acceptor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | aldose 1-epimerase activity | |
Molecular Function | carbohydrate binding | |
Biological Process | galactose catabolic process via UDP-galactose | |
Biological Process | glucose metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldose 1-epimerase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922I3N2
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length369
- Mass (Da)42,591
- Last updated2023-02-22 v1
- Checksum500E2F9CE9D0C287
Keywords
- Technical term