A0A922I3N2 · A0A922I3N2_DERFA

Function

function

Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; galactose metabolism.
Carbohydrate metabolism; hexose metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site81-82beta-D-galactose (UniProtKB | ChEBI)
Active site185Proton donor
Binding site185-187beta-D-galactose (UniProtKB | ChEBI)
Binding site252beta-D-galactose (UniProtKB | ChEBI)
Active site331Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionaldose 1-epimerase activity
Molecular Functioncarbohydrate binding
Biological Processgalactose catabolic process via UDP-galactose
Biological Processglucose metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldose 1-epimerase
  • EC number

Gene names

    • ORF names
      DERF_005531
      , HUG17_3485

Organism names

  • Taxonomic identifier
  • Strains
    • Derf
    • JKM2019
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922I3N2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the aldose epimerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    42,591
  • Last updated
    2023-02-22 v1
  • Checksum
    500E2F9CE9D0C287
MPIEKTTFHEGGDNDNVVTLYSLTNGRLTVKIIDYGATIIQIRYPDRDHIERDVVLGFDEFASYKSKLNPYFGSTIGRVANRIAKGTFRLNEQQYQLYQNNGENSLHGGLIGFDKRQWKLSNEADRSITLMYESFDGEEGYPGTLIIKVRFEITDSDELQIEYEAQLKNQDLLNVNKTIVSLTNHSYFNLNGCYDQDSLNVLDHKICLYAREFLEVDDDLIPTGRILPIKDTVMEFAEQPLRTIGERKFPYDHCYVLVNDSIEWKCTTRRPLRLAAEVYSQRTGIKMSFMTDEPAFQFYIGGFIPEHGLQTKKTQTSEMISLGKNSGFCLEAQRFPDAINHDGWRKQVILATNDIYRQQTIYQFKIANI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SDOV01000007
EMBL· GenBank· DDBJ
KAH7639452.1
EMBL· GenBank· DDBJ
Genomic DNA
ASGP02000002
EMBL· GenBank· DDBJ
KAH9521917.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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