A0A922I323 · A0A922I323_DERFA
- Proteinphospholipase A2
- GenePLA2G6_1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1086 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 721 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 842 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell presynaptic membrane | |
Cellular Component | mitochondrion | |
Cellular Component | other organism cell membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium-independent phospholipase A2 activity | |
Molecular Function | toxin activity | |
Biological Process | exocytosis | |
Biological Process | lipid catabolic process | |
Biological Process | positive regulation of ceramide biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namephospholipase A2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922I323
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 223-255 | ANK | ||||
Sequence: DQWSPLHIAVSLSNMYIVGLMLKSGMDVFIVDS | ||||||
Repeat | 489-521 | ANK | ||||
Sequence: AGDTALHFSVANGYIITIQLLLIFGARINIRNK | ||||||
Region | 543-579 | Disordered | ||||
Sequence: NDRRLDDKNQSSRMTTTPETHNRQQQQAANRSSTKNN | ||||||
Compositional bias | 553-579 | Polar residues | ||||
Sequence: SSRMTTTPETHNRQQQQAANRSSTKNN | ||||||
Region | 619-645 | Disordered | ||||
Sequence: HHHHRKSEEEKKRKKQKSSSPNDDDNI | ||||||
Compositional bias | 630-645 | Basic and acidic residues | ||||
Sequence: KRKKQKSSSPNDDDNI | ||||||
Domain | 679-855 | PNPLA | ||||
Sequence: IILDGGINDQFMNPLIQIILLNELQQYLPRSLPEYFDIIAGTSFGFTTGCSLANGKKLFEILNFYLKLRSNFRKPLIRMQEQNTDRLEQTLLTMFNDPKTLADIRRQNNKHLILTTTVVDDIPVRLKIVDDQIENLTMWKACRISGLGAGLFKTIEHEGVPYFDGSLIAPNPTTDIL | ||||||
Motif | 719-723 | GXSXG | ||||
Sequence: GTSFG |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,086
- Mass (Da)125,893
- Last updated2023-02-22 v1
- Checksum4BFD493DDCCF4912
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 553-579 | Polar residues | ||||
Sequence: SSRMTTTPETHNRQQQQAANRSSTKNN | ||||||
Compositional bias | 630-645 | Basic and acidic residues | ||||
Sequence: KRKKQKSSSPNDDDNI |
Keywords
- Technical term