A0A922I2Y0 · A0A922I2Y0_DERFA
- ProteinPhosphodiesterase
- GenePDE1C
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 903 | Proton donor | |||
Binding site | 903-907 | AMP (UniProtKB | ChEBI) | |||
Binding site | 907 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 943 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 944 | AMP (UniProtKB | ChEBI) | |||
Binding site | 944 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 944 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1051 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1051 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 1102 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922I2Y0
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 170-207 | Disordered | |||
Compositional bias | 382-417 | Polar residues | |||
Region | 382-466 | Disordered | |||
Compositional bias | 433-466 | Polar residues | |||
Region | 550-619 | Disordered | |||
Region | 678-757 | Disordered | |||
Compositional bias | 711-733 | Acidic residues | |||
Compositional bias | 734-749 | Polar residues | |||
Domain | 826-1243 | PDEase | |||
Compositional bias | 1131-1155 | Polar residues | |||
Region | 1131-1199 | Disordered | |||
Compositional bias | 1156-1170 | Acidic residues | |||
Compositional bias | 1182-1199 | Polar residues | |||
Region | 1236-1259 | Disordered | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,259
- Mass (Da)142,073
- Last updated2023-02-22 v1
- Checksum28506A9E519B8851
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 382-417 | Polar residues | |||
Compositional bias | 433-466 | Polar residues | |||
Compositional bias | 711-733 | Acidic residues | |||
Compositional bias | 734-749 | Polar residues | |||
Compositional bias | 1131-1155 | Polar residues | |||
Compositional bias | 1156-1170 | Acidic residues | |||
Compositional bias | 1182-1199 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ASGP02000003 EMBL· GenBank· DDBJ | KAH9517066.1 EMBL· GenBank· DDBJ | Genomic DNA |