A0A922I2Y0 · A0A922I2Y0_DERFA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

112591002003004005006007008009001,0001,1001,200
Type
IDPosition(s)Description
Active site903Proton donor
Binding site903-907AMP (UniProtKB | ChEBI)
Binding site907Zn2+ 1 (UniProtKB | ChEBI)
Binding site943Zn2+ 1 (UniProtKB | ChEBI)
Binding site944AMP (UniProtKB | ChEBI)
Binding site944Zn2+ 1 (UniProtKB | ChEBI)
Binding site944Zn2+ 2 (UniProtKB | ChEBI)
Binding site1051AMP (UniProtKB | ChEBI)
Binding site1051Zn2+ 1 (UniProtKB | ChEBI)
Binding site1102AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      PDE1C
    • ORF names
      DERF_007766

Organism names

  • Taxonomic identifier
  • Strain
    • Derf
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922I2Y0

Proteomes

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region170-207Disordered
Compositional bias382-417Polar residues
Region382-466Disordered
Compositional bias433-466Polar residues
Region550-619Disordered
Region678-757Disordered
Compositional bias711-733Acidic residues
Compositional bias734-749Polar residues
Domain826-1243PDEase
Compositional bias1131-1155Polar residues
Region1131-1199Disordered
Compositional bias1156-1170Acidic residues
Compositional bias1182-1199Polar residues
Region1236-1259Disordered

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,259
  • Mass (Da)
    142,073
  • Last updated
    2023-02-22 v1
  • Checksum
    28506A9E519B8851
MNLSSSTILLLFYSHKWYLLSSMIRSIFYYYYYWSSSLLNNHHHHYYYHENEAFNNNKINELRNIIYETYRFYNCLQFSFESLILLLITKISMTDDIKKLFRLRGRSSSSSFASTSTSTSVSSPSSSSSSSATTTTTSTIKIGANNQQLQPISTTATATTLSLSSSPISSSSSSTIIGRSKTQPSSPSLTPSPQPTSTSTSSSSSNPIDIINNTLHKCINYYHHHHPRRRRFSSTSSCSSSTLTTNVVIPPPSPPPSLIAAKSLLSNHHLQQQHTPLLLTKNNKLSINQEQNVRPSSAASSFTTIRQPQSMIMDQMNDNINQKPQLPPRPSSVVSATRIGDDNSGGHYQELRHQQSEDTLTSILNNEEKNTASIVSDERLTSTLTSSDGQKKAIITKTTSSSTTSHHEKIFRPQNSTETAPDDDKMMAEAAKTLTSHEQQQQQQSSNLTKTTPISRSGSGSGGGHQQNFEPIVDTLEVCDKAAARLRELAKHLEHGDIPNEVLQKTFQYAAYVLDTVSMDETRRRCKLIQQQHHHNQQQQQQLNRYYHNRGHGTQQQQQQQKQKSCPRLLRSQSTASSSSPPPSLSSSSSTTHQQQLPPPSSPSQQHQPSSSSSSSSMINVAKESSKIFNNGQHTLPCQSKSNNNNNNKNNNENNNNNIDPSMPNSIKSKIDSVKKAILDQVDPQKKKKKKKLSTNNDNNNIKNIDINNDHNDDDDDDDDDDDDDDDDDGDITNNNDSYSNMNKISMMEKNSQDSRRLLDEEDELAEVKPDAVPSEVREWLTSTFTRNQVSTRNRSDDKPKFRSVANAIRAGIMVDRIYRRLFSATTIQIAPEVSNFLKGTDEWSFDVFSLNQLQQGKVLRNLATDLLNRYGLIHKFKIPTSNLDSFLSQVELGYQKYQNPYHNNLHAADVTQTVHYLLWVTGLAQWLTDLEIFATLVAAIIHDYQHTGTTNNFHIMSGSEISLLYNDRSVLENFHISEAFRVIRKDDANIVANLSREEYREFRTLIIEMVIATDMSTHFQQIKTLKTILSHQDFVLDKQKGLSYILHSADISHPSKNFDLHQRWTLLLMEEFFRQGDMERELGLAYSPLCDRNSTLIPQSQIGFIEFIVYPTMELCGDLIERVYEHLNSSSSSSSTSTTTTVTATATTMATTSVDIIEEEEDNDDQKSSNDNEDDLKPKQQQQQISRNSSTTTTTNSSATVITTTTPVFNMVINSSTRKLYRPWLQYLDQNKTKWQQKATLEELKPKPPQQQQQQPGE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias382-417Polar residues
Compositional bias433-466Polar residues
Compositional bias711-733Acidic residues
Compositional bias734-749Polar residues
Compositional bias1131-1155Polar residues
Compositional bias1156-1170Acidic residues
Compositional bias1182-1199Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASGP02000003
EMBL· GenBank· DDBJ
KAH9517066.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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