A0A922HXH0 · A0A922HXH0_DERFA

Function

function

Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
    This reaction proceeds in the forward
    and the backward
    directions.
  • L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
    This reaction proceeds in the forward
    and the backward
    directions.
  • (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
    This reaction proceeds in the backward direction.
  • N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine
    This reaction proceeds in the forward direction.
  • N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
    This reaction proceeds in the forward
    and the backward
    directions.
  • N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
    This reaction proceeds in the forward
    and the backward
    directions.
  • N-(9Z-octadecenoyl)-L-asparagine + H2O = L-asparagine + (9Z)-octadecenoate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-L-glutamine + H2O = L-glutamine + (9Z)-octadecenoate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
    This reaction proceeds in the forward
    and the backward
    directions.
  • N-(9Z-octadecenoyl)-L-lysine + H2O = L-lysine + (9Z)-octadecenoate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-L-methionine + H2O = (9Z)-octadecenoate + L-methionine
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-L-serine + H2O = L-serine + (9Z)-octadecenoate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-L-tryptophan + H2O = L-tryptophan + (9Z)-octadecenoate
    This reaction proceeds in the forward direction.
  • N-(9Z-octadecenoyl)-L-tyrosine + H2O = L-tyrosine + (9Z)-octadecenoate
    This reaction proceeds in the forward direction.
  • N-hexadecanoyl-L-phenylalanine + H2O = hexadecanoate + L-phenylalanine
    This reaction proceeds in the forward direction.
  • N-octadecanoyl-L-phenylalanine + H2O = octadecanoate + L-phenylalanine
    This reaction proceeds in the forward direction.
  • an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate
    This reaction proceeds in the forward
    and the backward
    directions.
    EC:3.5.1.14 (UniProtKB | ENZYME | Rhea)
  • an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
    This reaction proceeds in the forward
    and the backward
    directions.
    EC:3.5.1.114 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; fatty acid metabolism.

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Molecular Functionmetal ion binding
Molecular Functionpeptidase activity
Biological Processamide biosynthetic process
Biological Processamide catabolic process
Biological Processamino acid metabolic process
Biological Processcellular lipid metabolic process
Biological Processproteolysis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Peptidase M20 dimerisation domain-containing protein

Gene names

    • ORF names
      DERF_009985

Organism names

  • Taxonomic identifier
  • Strain
    • Derf
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922HXH0

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain256-400Peptidase M20 dimerisation

Sequence similarities

Belongs to the peptidase M20A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    520
  • Mass (Da)
    59,549
  • Last updated
    2023-02-22 v1
  • Checksum
    A9A73A71F6AD0B06
MKIKICDVIKVAIFLLIFSFTFLALIVICRTLLVQQYMVNSYCTMNENYVPLYGINHNAITAERGIFERLQDALKIRTITRRPKHYDRDEILRFHRFLNSNFPLIHSSPLVELTIVNELSLLYKINGSNQQLKPYMLLAHMDVVPVQEDMWDFHPFEGKIHNDYIYGRGALDLKSVVMGIMESLEFILENKNPIVRSFYIAIGHDEEGRGLDGAQQIAKYMVENNMDNVEYILDEGPYIFRNAIPGVSRDVAMIGVAEKGLVNIKLSTDGAVGHSSLPPKQTSIVRMAKAVSKLNADSHPNLFGYGPEKDMIEALAPYCSLPYRILYTNLWLFSPIVAKLLENDKLMNSFIRTTTAVTIFTSGIKDNVLPGKAEAIVNHRIYPLNRVEDVLRRDIEIIDDDQINVEVLGVAIQPHPISSYGHDSFGYQTIRQSIQQVFPDIAIIPGMMYAATDTRWYLNFTNNIYRFSPGYITMEQFSIVHGHNERISKDNYLKLVNFYHHIIMNSNDAQVDIAFFKDEF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASGP02000004
EMBL· GenBank· DDBJ
KAH9511533.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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