A0A922HV49 · A0A922HV49_DERFA

Function

function

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (2E)-decenoyl-[ACP] + H+ + NADPH = decanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-dodecenoyl-[ACP] + H+ + NADPH = dodecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-hexadecenoyl-[ACP] + H+ + NADPH = hexadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-hexenoyl-[ACP] + H+ + NADPH = hexanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-octadecenoyl-[ACP] + H+ + NADPH = NADP+ + octadecanoyl-[ACP]
    This reaction proceeds in the forward direction.
  • (2E)-octenoyl-[ACP] + H+ + NADPH = NADP+ + octanoyl-[ACP]
    This reaction proceeds in the forward direction.
  • (2E)-tetradecenoyl-[ACP] + H+ + NADPH = NADP+ + tetradecanoyl-[ACP]
    This reaction proceeds in the forward direction.
  • (3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • 3-oxobutanoyl-[ACP] + H+ + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxodecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxododecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxohexadecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxohexanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxooctadecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxooctanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxotetradecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • H+ + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H+ + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H+ + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H+ + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H2O + hexadecanoyl-[ACP] = H+ + hexadecanoate + holo-[ACP]
    This reaction proceeds in the forward direction.
    EC:3.1.2.14 (UniProtKB | ENZYME | Rhea)
  • H2O + tetradecanoyl-[ACP] = H+ + holo-[ACP] + tetradecanoate
    This reaction proceeds in the forward direction.
    EC:3.1.2.14 (UniProtKB | ENZYME | Rhea)
  • a (3R)-hydroxyacyl-[ACP] + NADP+ = a 3-oxoacyl-[ACP] + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.1.1.100 (UniProtKB | ENZYME | Rhea)
  • a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
    EC:4.2.1.59 (UniProtKB | ENZYME | Rhea)
  • a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.3.1.39 (UniProtKB | ENZYME | Rhea)
  • a fatty acyl-[ACP] + H+ + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
    EC:2.3.1.41 (UniProtKB | ENZYME | Rhea)
  • acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.38 (UniProtKB | ENZYME | Rhea)
  • acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
    EC:2.3.1.85 (UniProtKB | ENZYME | Rhea)
  • acetyl-[ACP] + H+ + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • butanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • decanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • dodecanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site922Proton acceptor; for dehydratase activity
Active site1082Proton donor; for dehydratase activity

GO annotations

AspectTerm
Molecular Function3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Functionfatty acid synthase activity
Molecular Functionhydrolase activity
Molecular Functionoxidoreductase activity
Molecular Functionphosphopantetheine binding
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • ORF names
      DERF_011738

Organism names

  • Taxonomic identifier
  • Strain
    • Derf
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922HV49

Proteomes

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain14-425Ketosynthase family 3 (KS3)
Region886-1018N-terminal hotdog fold
Domain886-1165PKS/mFAS DH
Region1033-1165C-terminal hotdog fold
Domain2288-2365Carrier

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,688
  • Mass (Da)
    304,964
  • Last updated
    2023-02-22 v1
  • Checksum
    D9EBB74F49BF7704
MEPLSKIANECPIKEDIVISGISGRFPEADNMDEFAQKLFSGEDMVTRDDRRWPVEINDSLGSRTGKLKSLDKFDSSFFSMLTYLSHSMDPVSRIVLETTYEAFHDAGVCPHQIRGSNTGVYFGINTIAQADGLPQDDFNDIFTKEAAFWVYGNSKVLYANRISFLFDFQGPSLVIDTACSASLVALATAMNDIRMGVCDTAVVATGNLVPAPFGNSIYSCVGLLASDGKCKVWDKRADGFVRSETIGAVILQRRSQAKRVYATVLHSKVNSDGFKSVGLFAPYWLRQKDLMVSTYEEAGVDPNDLVYFEAHGTGTNVGDPQEAKAIAEAYCKHREQPLLVGAVKSNLGHSEGSSGLNSVAKIVVAFENKCIPANLHFNEPKQEIYAIVNKQIEPVIKNTKFPNGIVGVNSFGVGGVNAHILLKSNDKELTPESYEICKPIPRLVTIAGRTEEGVNMMFDFIKNNPEKVHRDFLALLNESMKTGWVESSSNFPQRGYMIIKEKPNNTEFTTINIECGEVKVPKYEYDCKITSTGMEYPVWLVFSGMGSQWLTMATSMMSLEPFARSIHQSAAVLKPMGIDLIELLTKNDPELWKSTVNPFVAITSMQVALYDVIKLLNLKIEGIIGHSFGEVACAYADGCLTLEQAVLTSFWRGKIVEQSKLPRGVLAAIGLSWEEAKKRCPPGIVPACHNGSDSVTISGLYEETKKFVEKLQAENVFARLVAGGEYPYHSPHMNAVAPDLMAALNKIIPEPKKRSSKWISTSFDKSNWYIEDACYASAKYFTNNLVSPVLFNEGMNEISKDSIAIEVAPHSLFDSIFKRCYQRHHYIGLMKRNEPDNLNFFLTALGKIYTFGMNLDIENLYPRVEWPVARSTQSLSSLVHWDHSKSFYVKKYPEFHNFSTASDFYVKISVHETDWHFLRDHAVEGKALFPATGYLYLVWRRVANHIGQPWSKTPVHFENVRFHRPTLVSETSDIKFTIRLLQGSGEFLVFEANNLVCTGKATVMDNDNGLEVQDTIEPAIEEDYKQRHSSEFDYLSTREIYKELRIRGYDYGTKFQGLTEARSDGAIGKVKWDGHFISFMDSMLHISLIALPLRALFVPVGFESVRIDPKVLFGEIERVKQEKKKTEEEEFHLKREFLYFSDKTKENETLEKDFSNRVEGAINKEEVDQDNQESRADLPIQFYETAFMKNEDNKISLIPIIFDGNNRSIATKGLEVKGMIPFPVPRKIDQKGLILEKYSHMPYLDKEQSRLNEDKHKELMDYIEMCNYLATLLVLDKKVAKPEMKELVVQGKLNDLIRHYTKFVEMQEVNKYRVFMLLKDLLELKVEKMEDGDEKLMMSCCVAEDKLNGEGGLNNELLTKHDLSADLAVLLQTNEHLVRPLIDTVLENSSDRNNLKMIEVNPAQYLYAWRIVQLIKTSYVGNLNIDYTYANTGSQILNKELESLNMKSIEWNQSTNSFINDINTMDLILYRLTDGVVENWSIDRQLEAFYDALKENGFLMVIARNDLNKVESTLYKCFNIDPKREIIRSGVVDEFIKAAKAASFGLVGTKTSIYGCTALLFRKLKMVYDPAEFNVLKIVNFEYDTWVDKLKALMAQSKDDNKPLWLVANEKYTGVVGMVNCLRLEPGGVNVRCILDLDNSLPDQIDFEKSPFNEIGYMDLVFNVYKQGQWGSFRFITLPDECEKVETEYAYLDIATRGDLSTFNWYESDHKHFNQNCQSRPRKRYGHDVMLATGRIQPGPESAIFNCVIGLEFSGRRRDNGKRVMGMVPFKGFATTITSFEDFLWDVPDDWSLEEAASIPVVYSTALYALIVRGQLREGDKVLIHSAAGGVGQAAIRICQDYKCEIFVTVGNQRKRTFLKEEFGIPDDHIFNSRDISFERLIKDRTKGLGVDIVLNSLAEDKLQASLRCLGLNGRFLEIGKYDMQMNKPIGMFAFLQNISFHGVCLDAYFREGFDSPNLKRFMKRMTDLLYDGIKRGVVKPIQRTSYRWNEVEQAFRYMSTGKHIGKVIIKMREEEKEKQILAKPLKVIANRRTSFNPSKSYVIAGGLGGFGLELLYWMVMRGAKKFVLSSRGGLKNSYQKLYFKRLKELSKFISIFDIDVTIATDNVITEDGARALIDEAMTKGPVGGLFNLTLVLHDAFVENQTAETFIEVCSPKLTGLANLDKISRAKCPEIDYFVCFSSLTAGRGNAGQINYGYANSAMERICECRRAEGLPGTAIQWGPIGDVGVVAEHLLVDADDKKQEDMLKLFGGISLQRIASCLEVLDRLLQVGAPVLSSLIKSNLEDNSNQSEDDILDQLCAHLNVDKRSREETIGDAGLDSMTVVEIQQRLERDYEVSLSVADVKRITIGEIKDFRDGKREGLKSFAEDIKKTRMHLANIRFEIASEPYTIVCPHQEVSKMKPIFFLPPIEGIYESLKEIIMDMAKHRPVITLNWMRKMNELNNIKKVAEYFKGVLAKLEPKGEHEIVGHSFGAIVGIHMCRKAVPIKTMIVLDPMDVSNFKEEFDRNEKVEMILSYLRNFMSERLVDKVRKEALSVKNEQECIQRIADVLKSHGGKAINSKDIDDIIKDSFVRSEMILKYQQKNIRKLRMFGRDFTQKTVQKMMKKITVNVSVIKRMTQESEIDKLNHILLTSYGIARKDFIGRFDVYQVIGNEEEYLTTHLHYITKLIKLKLTLITEEEAQNLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASGP02000005
EMBL· GenBank· DDBJ
KAH9507034.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp