A0A922HGJ6 · A0A922HGJ6_DERFA
- ProteintRNA (guanine-N(7)-)-methyltransferase
- GeneMETTL1_1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.
Catalytic activity
- guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine
Pathway
tRNA modification; N7-methylguanine-tRNA biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 79 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 102-103 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: EI | ||||||
Binding site | 135-136 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: NA | ||||||
Binding site | 155 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Active site | 158 | |||||
Sequence: D | ||||||
Binding site | 232-234 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: TEE |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | tRNA methyltransferase complex | |
Molecular Function | tRNA (guanine(46)-N7)-methyltransferase activity | |
Molecular Function | tRNA binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (guanine-N(7)-)-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922HGJ6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MTEYSTSIEQKPPPESSSSSLS |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)30,950
- Last updated2023-02-22 v1
- Checksum1773F39890A7335C
Keywords
- Technical term